| pubmed-article:3459152 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3459152 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:3459152 | lifeskim:mentions | umls-concept:C0004793 | lld:lifeskim |
| pubmed-article:3459152 | lifeskim:mentions | umls-concept:C0205360 | lld:lifeskim |
| pubmed-article:3459152 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:3459152 | pubmed:dateCreated | 1986-7-9 | lld:pubmed |
| pubmed-article:3459152 | pubmed:abstractText | We report the complete thermodynamic library of all 10 Watson-Crick DNA nearest-neighbor interactions. We obtained the relevant thermodynamic data from calorimetric studies on 19 DNA oligomers and 9 DNA polymers. We show how these thermodynamic data can be used to calculate the stability and predict the temperature-dependent behavior of any DNA duplex structure from knowledge of its base sequence. We illustrate our method of calculation by using the nearest-neighbor data to predict transition enthalpies and free energies for a series of DNA oligomers. These predicted values are in excellent agreement with the corresponding values determined experimentally. This agreement demonstrates that a DNA duplex structure thermodynamically can be considered to be the sum of its nearest-neighbor interactions. Armed with this knowledge and the nearest-neighbor thermodynamic data reported here, scientists now will be able to predict the stability (delta G degree) and the melting behavior (delta H degree) of any DNA duplex structure from inspection of its primary sequence. This capability should prove valuable in numerous applications, such as predicting the stability of a probe-gene complex; selecting optimal conditions for a hybridization experiment; deciding on the minimum length of a probe; predicting the influence of a specific transversion or transition on the stability of an affected DNA region; and predicting the relative stabilities of local domains within a DNA duplex. | lld:pubmed |
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| pubmed-article:3459152 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:3459152 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3459152 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3459152 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:3459152 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:3459152 | pubmed:author | pubmed-author:FrankRR | lld:pubmed |
| pubmed-article:3459152 | pubmed:author | pubmed-author:BreslauerK... | lld:pubmed |
| pubmed-article:3459152 | pubmed:author | pubmed-author:BlöckerHH | lld:pubmed |
| pubmed-article:3459152 | pubmed:author | pubmed-author:MarkyL ALA | lld:pubmed |
| pubmed-article:3459152 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3459152 | pubmed:volume | 83 | lld:pubmed |
| pubmed-article:3459152 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3459152 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3459152 | pubmed:pagination | 3746-50 | lld:pubmed |
| pubmed-article:3459152 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3459152 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3459152 | pubmed:articleTitle | Predicting DNA duplex stability from the base sequence. | lld:pubmed |
| pubmed-article:3459152 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3459152 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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