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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
1988-6-7
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pubmed:abstractText |
Some of the statistical properties of a simple two-stage model of carcinogenesis are explored. The implications of additive treatment effects versus independent treatment effects on the shape of the dose-response curve are considered. Response that is low-dose linear results in the cases where the mutation rates are affected by dose or in the cases where treatment changes the birth rate/death rate of initiated cells in an additive fashion. Independent treatment effects lead to non-low-dose linear response when the survival of initiated cells is affected by treatment. A computer simulation experiment was performed that examined the ability of animal carcinogenesis data to differentiate between various forms of this simple two-stage model. It is shown that animal carcinogenicity experiments do not contain enough data to adequately describe the difference between these two types of effects.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-13051507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-13172380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-283278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-2983882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-3615992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-3731095,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-517520,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-626986,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-6789853,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-6873019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-6931935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-6941039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-7013284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3447890-7023560
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0091-6765
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
76
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
125-31
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3447890-Animals,
pubmed-meshheading:3447890-Carcinogens,
pubmed-meshheading:3447890-Clone Cells,
pubmed-meshheading:3447890-Cocarcinogenesis,
pubmed-meshheading:3447890-Dose-Response Relationship, Drug,
pubmed-meshheading:3447890-Models, Biological,
pubmed-meshheading:3447890-Neoplasms, Experimental,
pubmed-meshheading:3447890-Risk
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pubmed:year |
1987
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pubmed:articleTitle |
Statistical properties of a two-stage model of carcinogenesis.
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pubmed:affiliation |
National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
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pubmed:publicationType |
Journal Article
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