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rdf:type |
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lifeskim:mentions |
umls-concept:C0022925,
umls-concept:C0031715,
umls-concept:C0032961,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035820,
umls-concept:C0086597,
umls-concept:C0205054,
umls-concept:C0392747,
umls-concept:C0441655,
umls-concept:C0443172,
umls-concept:C1415615
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pubmed:issue |
3
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pubmed:dateCreated |
1988-3-15
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pubmed:abstractText |
1. The expressed and total (completely dephosphorylated) activities of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase were measured in microsomal fractions isolated from cold-clamped liver samples from female rats in various stages of the reproductive cycle. 2. There was little change in total HMG-CoA reductase activity during pregnancy and early lactation, but after 2 days post partum there was a marked increase in total activity. 3. The expressed/total activity ratio of HMG-CoA reductase showed a profound decrease during the last 2 days of pregnancy. The fraction of the enzyme in the active form increased progressively during the first 2 days of lactation. 4. The combined effect of these changes was that the expressed activity of HMG-CoA reductase changed in parallel with the known changes in the hepatic rate of cholesterogenesis during pregnancy and lactation in vivo.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-2866126,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-2882748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-2995526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-3512302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-3545301,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-3904728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-4025547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-486145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-508293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-6087794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-6097245,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-6137213,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-6146533,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-6163836,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-6365080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-6466299,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-6683964,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-6995544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-7199367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-7306561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-769497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3435498-779838
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
248
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
993-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3435498-Animals,
pubmed-meshheading:3435498-Female,
pubmed-meshheading:3435498-Hydroxymethylglutaryl CoA Reductases,
pubmed-meshheading:3435498-Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent,
pubmed-meshheading:3435498-Lactation,
pubmed-meshheading:3435498-Liver,
pubmed-meshheading:3435498-Microsomes, Liver,
pubmed-meshheading:3435498-Phosphorylation,
pubmed-meshheading:3435498-Pregnancy,
pubmed-meshheading:3435498-Pregnancy, Animal,
pubmed-meshheading:3435498-Rats,
pubmed-meshheading:3435498-Rats, Inbred Strains
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pubmed:year |
1987
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pubmed:articleTitle |
Role of reversible phosphorylation in mediating changes in the activity of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase during pregnancy and lactation in the rat.
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pubmed:affiliation |
Hannah Research Institute, Ayr, Scotland, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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