Linked Life Data

3429059

Source:http://linkedlifedata.com/resource/pubmed/id/3429059

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1988-3-3
pubmed:abstractText
We investigated the vasodilating effect of diltiazem on basal as well as digoxin-dependent splanchnic and systemic hemodynamics in 12 normotensive men, using the hepatic venous catheter technique, the thermodilution method and systolic time intervals. After baseline measurements, diltiazem was administered by a primed-constant infusion (2.5 micrograms/kg/min) in 6 out of 12 subjects. Following an equilibration period of diltiazem infusion, 1 mg digoxin was infused concomitantly over 15 min and hemodynamic changes were determined over 105 min. Control trials with digoxin and concomitant saline infusion were also performed in 7 out of 12 subjects. Diltiazem medication alone lowered only systolic blood pressure without affecting splanchnic hemodynamics. Digoxin without comedication provoked an increase in systolic blood pressure, a decrease in heart rate, mean pulmonary artery pressure and total electromechanical systole (positive inotropic effect), and significantly reduced splanchnic blood flow and increased splanchnic vascular resistance. During concomitant diltiazem infusion, digoxin did not alter splanchnic hemodynamics while the shortening of total electromechanical systole remained unchanged. We conclude, that diltiazem attenuates digoxin-induced splanchnic vasoconstriction and therefore, might be useful in the treatment of digitalis-dependent splanchnic vascular insufficiency.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0174-4879
pubmed:author
pubmed:issnType
Print
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
553-7
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1987
pubmed:articleTitle
Diltiazem counteracts digitalis-dependent splanchnic vasoconstriction in man.
pubmed:affiliation
First Medical University Clinic, Division of Clinical Pharmacology, Vienna, Austria.
pubmed:publicationType
Journal Article