| pubmed-article:3426545 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3426545 | lifeskim:mentions | umls-concept:C1257740 | lld:lifeskim |
| pubmed-article:3426545 | lifeskim:mentions | umls-concept:C0597295 | lld:lifeskim |
| pubmed-article:3426545 | lifeskim:mentions | umls-concept:C0005919 | lld:lifeskim |
| pubmed-article:3426545 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3426545 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
| pubmed-article:3426545 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:3426545 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:3426545 | lifeskim:mentions | umls-concept:C1707271 | lld:lifeskim |
| pubmed-article:3426545 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3426545 | pubmed:dateCreated | 1988-1-27 | lld:pubmed |
| pubmed-article:3426545 | pubmed:abstractText | 1. Synthetic peptides corresponding to the five, seven, nine and eleven C-terminal amino acids of the tetradecapeptide bombesin as well as bombesin itself and gastrin-releasing peptide have been evaluated in Swiss 3T3 cells in order to define the minimal peptide length needed for biological responsiveness. 2. Gastrin-releasing peptide, bombesin, the undecapeptide and nonapeptide had nearly equipotent abilities to compete for binding of labelled gastrin-releasing peptide to the cell receptors and showed half-maximal competition at 5-10 nM. The heptapeptide and pentapeptide were ineffective. 3. Cross-linking experiments demonstrated specific binding of gastrin-releasing peptide to a 100 kDa receptor subunit. 4. Total cell protein synthesis was stimulated equally by the nonapeptide and longer peptides with a half-maximal effect at 0.5 nM, while a more than 1000-fold higher concentration of the heptapeptide was required to produce a similar response. Comparable results were found when insulin was also present. 5. Neither an inhibition of protein breakdown nor a stimulation of DNA labelling could be demonstrated by bombesin or gastrin-releasing peptide. 6. We conclude that a C-terminal peptide ligand comprising more than seven but no more than nine amino acids is required to achieve high-affinity binding and receptor-mediated responses via the bombesin receptor. | lld:pubmed |
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| pubmed-article:3426545 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3426545 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3426545 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3426545 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3426545 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3426545 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:3426545 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:3426545 | pubmed:author | pubmed-author:BallardF JFJ | lld:pubmed |
| pubmed-article:3426545 | pubmed:author | pubmed-author:WallaceJ CJC | lld:pubmed |
| pubmed-article:3426545 | pubmed:author | pubmed-author:GargoskyS ESE | lld:pubmed |
| pubmed-article:3426545 | pubmed:author | pubmed-author:UptonF MFM | lld:pubmed |
| pubmed-article:3426545 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3426545 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:3426545 | pubmed:volume | 247 | lld:pubmed |
| pubmed-article:3426545 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3426545 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3426545 | pubmed:pagination | 427-32 | lld:pubmed |
| pubmed-article:3426545 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3426545 | pubmed:meshHeading | pubmed-meshheading:3426545-... | lld:pubmed |
| pubmed-article:3426545 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3426545 | pubmed:articleTitle | C-terminal bombesin sequence requirements for binding and effects on protein synthesis in Swiss 3T3 cells. | lld:pubmed |
| pubmed-article:3426545 | pubmed:affiliation | Department of Biochemistry, University of Adelaide, South Australia. | lld:pubmed |
| pubmed-article:3426545 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3426545 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3426545 | lld:pubmed |
