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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1978-4-17
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pubmed:abstractText |
Concentration versus radiosensitizing effect curves have been determined for four E. coli strains with two nitroaromatic sensitizers. The data are consistent with a simple competition kinetic model of sensitization, and K values for Ro 07-0582 are reported. An empirical relationship, DMF=alpha o.e.r., relating the dose-modifying factor produced by a given concentration of sensitizer to the oxygen-enhancement ratio of a bacterium was found to hold for all the mutants tested for values of alpha greater than 1/o.e.r. The limiting value of alpha at high concentrations of sensitizer was 0.75. Some implications of this relationship and the limiting value of alpha are discussed.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
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pubmed:issn |
0020-7616
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
33
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
41-5
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pubmed:dateRevised |
2000-12-18
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pubmed:meshHeading |
pubmed-meshheading:342430-Dose-Response Relationship, Drug,
pubmed-meshheading:342430-Escherichia coli,
pubmed-meshheading:342430-Mutation,
pubmed-meshheading:342430-Nitroimidazoles,
pubmed-meshheading:342430-Oxygen,
pubmed-meshheading:342430-Propiophenones,
pubmed-meshheading:342430-Radiation-Sensitizing Agents
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pubmed:year |
1978
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pubmed:articleTitle |
The effect of the electron affinic sensitizers Ro 07-0582 and Ro 03-6156 on the survival of several E. coli mutants.
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pubmed:publicationType |
Journal Article
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