Linked Life Data

3420302

Source:http://linkedlifedata.com/resource/pubmed/id/3420302

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1988-10-20
pubmed:abstractText
Prolonged sodium restriction was found to induce a notable hypertrophy of rat zona glomerulosa (ZG) cells and a significant rise in the basal plasma aldosterone concentration. Chronic prolactin administration significantly furthered the effects of sodium restriction. Dopamine infusion (3 mg/kg day for 7 days) did not apparently affect ZG morphology and function in the control rats, while it significantly counteracted the effects of sodium deprivation combined or not with prolactin administration. However, the action of dopamine was less intense in sodium-deprived rats treated with prolactin. These findings confirm the view that the dopaminergic system exerts a tonic inhibitory effect, modulated by the sodium balance, on the growth and secretory activity or rat ZG. Moreover, they suggest that the mechanism(s) underlying the antiadrenoglomerulotrophic action of dopamine in rats only partially involve(s) the well-known suppression of the hypophyseal release of prolactin.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0300-9130
pubmed:author
pubmed:issnType
Print
pubmed:volume
188
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-16
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of prolonged dopamine infusion on the zona glomerulosa of sodium-restricted rats treated or not with prolactin: stereology and plasma hormone concentrations.
pubmed:affiliation
Dept. of Anatomy, University of Padua, Italy.
pubmed:publicationType
Journal Article