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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
7
|
| pubmed:dateCreated |
1988-10-17
|
| pubmed:abstractText |
A novel aminoglycoside antibiotic, boholmycin, was produced by Streptomyces hygroscopicus H617-25 isolated from a soil sample collected in Bohol Island, the Philippines. It has a pseudotetrasaccharide structure composed of a heptose, two aminosugars and dicarbamoyl-scyllo-inositol. Intrinsic antibacterial activity of boholmycin is weak but it exhibits broad spectrum activity against Gram-positive and Gram-negative bacteria including aminoglycoside-resistant strains. Boholmycin is non-toxic in mice at 1,000 mg/kg intravenously.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0021-8820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
855-61
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3417558-Aminoglycosides,
pubmed-meshheading:3417558-Animals,
pubmed-meshheading:3417558-Anti-Bacterial Agents,
pubmed-meshheading:3417558-Bacteria,
pubmed-meshheading:3417558-Chemical Phenomena,
pubmed-meshheading:3417558-Chemistry,
pubmed-meshheading:3417558-Fermentation,
pubmed-meshheading:3417558-Mice,
pubmed-meshheading:3417558-Streptomyces
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Boholmycin, a new aminoglycoside antibiotic. I. Production, isolation and properties.
|
| pubmed:affiliation |
Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.
|
| pubmed:publicationType |
Journal Article
|