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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
5
|
pubmed:dateCreated |
1988-9-27
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pubmed:abstractText |
When racemic primaquine was administered to rats, the majority of the residual primaquine excreted in urine was found to be the (+)-isomer. Using a liver microsome preparation, there was no selectivity in the metabolism of the (+)- and (-)-isomers; however, a liver fraction containing mitochondria and microsomes did show selectivity. In the latter preparation, there was a marked preference for the conversion of (-)-primaquine to (-)-carboxy-primaquine.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-3549
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
77
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pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
380-2
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3411455-Animals,
pubmed-meshheading:3411455-Chromatography, High Pressure Liquid,
pubmed-meshheading:3411455-Liver,
pubmed-meshheading:3411455-Male,
pubmed-meshheading:3411455-Microsomes, Liver,
pubmed-meshheading:3411455-Mitochondria, Liver,
pubmed-meshheading:3411455-Primaquine,
pubmed-meshheading:3411455-Rats,
pubmed-meshheading:3411455-Rats, Inbred Strains,
pubmed-meshheading:3411455-Stereoisomerism
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pubmed:year |
1988
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pubmed:articleTitle |
Differential metabolism of the enantiomers of primaquine.
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pubmed:affiliation |
Department of Medicinal Chemistry, University of Mississippi, University 38677.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't
|