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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1988-9-27
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pubmed:abstractText |
An antiserum raised against chemically acetylated histone H4 was found to recognize the epitope epsilon-N-acetyl lysine. Affinity-purified antibodies were used to fractionate oligo- and mononucleosomal chromatin fragments from the nuclei of 15-day chicken embryo erythrocytes. Antibody-bound chromatin was found to contain elevated levels of acetylated core histones. On probing with sequences of alpha D globin, an actively transcribed gene, the antibody-bound chromatin was 15- to 30-fold enriched relative to the input chromatin. Using ovalbumin sequences as a probe, no enrichment was observed. The results demonstrate directly that transcriptionally active genes carry acetylated core histones.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-14172992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-2443844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-276864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-3656449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-3703677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-3822820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-3949730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-4134752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-4186539,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-424287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-4633445,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-5219687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-5442820,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-6273837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-661981,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-667927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-673837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-7433098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3409869-948749
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0261-4189
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1395-402
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1988
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pubmed:articleTitle |
A direct link between core histone acetylation and transcriptionally active chromatin.
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pubmed:affiliation |
Biophysics Laboratories, Portsmouth Polytechnic, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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