| pubmed-article:3409546 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3409546 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:3409546 | lifeskim:mentions | umls-concept:C0699819 | lld:lifeskim |
| pubmed-article:3409546 | lifeskim:mentions | umls-concept:C0017622 | lld:lifeskim |
| pubmed-article:3409546 | lifeskim:mentions | umls-concept:C0597140 | lld:lifeskim |
| pubmed-article:3409546 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3409546 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:3409546 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3409546 | pubmed:dateCreated | 1988-10-6 | lld:pubmed |
| pubmed-article:3409546 | pubmed:abstractText | When an antigen is first presented via the gut, either priming or suppression of the systemic immune response may result. Many factors influence the outcome, including physico-chemical properties of the antigen. The aim of this study is to establish if wheat gliadin behaves as an oral immunogen or tolerogen. Mice reared on a gluten-free diet were fed gliadin, either as wheat flour in a standard rodent diet or as the purified molecule. Immune status (tolerant or sensitized) was then defined by measuring specific systemic immune responses after parenteral immunization of gliadin-fed and control mice. A single feed of 25 or 125 mg of purified gliadin resulted in a dose-dependent suppression of both cell-mediated and humoral immune responses. Similar oral tolerance was achieved by feeding mice with a gluten-containing diet for a week. Finally, mice reared on a normal, gluten-containing diet showed evidence of established oral tolerance, with significantly lower systemic immune response to gliadin than mice reared on gluten-free diet. These results indicate that gliadin is an effective oral tolerogen. In vivo studies on the immunogenicity of gliadins should be conducted in animals from gluten-free colonies. | lld:pubmed |
| pubmed-article:3409546 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3409546 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3409546 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3409546 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3409546 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3409546 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3409546 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3409546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3409546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3409546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3409546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3409546 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3409546 | pubmed:month | May | lld:pubmed |
| pubmed-article:3409546 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:3409546 | pubmed:author | pubmed-author:FergusonAA | lld:pubmed |
| pubmed-article:3409546 | pubmed:author | pubmed-author:TronconiVV | lld:pubmed |
| pubmed-article:3409546 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3409546 | pubmed:volume | 72 | lld:pubmed |
| pubmed-article:3409546 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3409546 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3409546 | pubmed:pagination | 284-7 | lld:pubmed |
| pubmed-article:3409546 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3409546 | pubmed:meshHeading | pubmed-meshheading:3409546-... | lld:pubmed |
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| pubmed-article:3409546 | pubmed:meshHeading | pubmed-meshheading:3409546-... | lld:pubmed |
| pubmed-article:3409546 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3409546 | pubmed:articleTitle | Gliadin presented via the gut induces oral tolerance in mice. | lld:pubmed |
| pubmed-article:3409546 | pubmed:affiliation | Gastro-Intestinal Unit, Western General Hospital, Edinburgh, UK. | lld:pubmed |
| pubmed-article:3409546 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3409546 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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