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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1988-10-6
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pubmed:abstractText |
When an antigen is first presented via the gut, either priming or suppression of the systemic immune response may result. Many factors influence the outcome, including physico-chemical properties of the antigen. The aim of this study is to establish if wheat gliadin behaves as an oral immunogen or tolerogen. Mice reared on a gluten-free diet were fed gliadin, either as wheat flour in a standard rodent diet or as the purified molecule. Immune status (tolerant or sensitized) was then defined by measuring specific systemic immune responses after parenteral immunization of gliadin-fed and control mice. A single feed of 25 or 125 mg of purified gliadin resulted in a dose-dependent suppression of both cell-mediated and humoral immune responses. Similar oral tolerance was achieved by feeding mice with a gluten-containing diet for a week. Finally, mice reared on a normal, gluten-containing diet showed evidence of established oral tolerance, with significantly lower systemic immune response to gliadin than mice reared on gluten-free diet. These results indicate that gliadin is an effective oral tolerogen. In vivo studies on the immunogenicity of gliadins should be conducted in animals from gluten-free colonies.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
284-7
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3409546-Administration, Oral,
pubmed-meshheading:3409546-Animals,
pubmed-meshheading:3409546-Antigens,
pubmed-meshheading:3409546-Diet,
pubmed-meshheading:3409546-Dose-Response Relationship, Immunologic,
pubmed-meshheading:3409546-Female,
pubmed-meshheading:3409546-Gliadin,
pubmed-meshheading:3409546-Glutens,
pubmed-meshheading:3409546-Hypersensitivity, Delayed,
pubmed-meshheading:3409546-Immune Tolerance,
pubmed-meshheading:3409546-Immunity, Cellular,
pubmed-meshheading:3409546-Immunoglobulin G,
pubmed-meshheading:3409546-Intestinal Mucosa,
pubmed-meshheading:3409546-Mice,
pubmed-meshheading:3409546-Mice, Inbred BALB C,
pubmed-meshheading:3409546-Plant Proteins
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pubmed:year |
1988
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pubmed:articleTitle |
Gliadin presented via the gut induces oral tolerance in mice.
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pubmed:affiliation |
Gastro-Intestinal Unit, Western General Hospital, Edinburgh, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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