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pubmed-article:3403869pubmed:abstractTextLate systemic-allergic reactions (defined as occurring between 30 minutes and 6 hours after injection) to inhalant allergen immunotherapy were prospectively studied in four allergy treatment centers; 35,674 injections were administered to 712 patients. Twenty-nine patients (4% of all patients) experienced 33 late reactions. Fifty-six injections (0.16% of all injections) were associated with the 33 late reactions. The most common clinical manifestation of a late reaction was urticaria. However, objective respiratory airway involvement, as manifested by wheezing and/or stridor, occurred in 10 (27%) of the late reactions. Delayed reactions involving wheezing and/or stridor were only related to injections from maintenance vials, and all these more severe reactions occurred no later than 60 minutes after injection. We conclude that late systemic-allergic reactions account for a significant percent of the total number of systemic-allergic reactions to inhalant allergen immunotherapy. It is our belief that a 60-minute postinjection waiting period for injections administered from maintenance vials of extract would enhance the safety of inhalant allergen immunotherapy.lld:pubmed
pubmed-article:3403869pubmed:languageenglld:pubmed
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pubmed-article:3403869pubmed:authorpubmed-author:SummersR JRJlld:pubmed
pubmed-article:3403869pubmed:authorpubmed-author:GreenbergM...lld:pubmed
pubmed-article:3403869pubmed:authorpubmed-author:GonzalezG EGElld:pubmed
pubmed-article:3403869pubmed:authorpubmed-author:KaufmanC RCRlld:pubmed
pubmed-article:3403869pubmed:authorpubmed-author:RosenblattC...lld:pubmed
pubmed-article:3403869pubmed:authorpubmed-author:TrusewychZ...lld:pubmed
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pubmed-article:3403869pubmed:volume82lld:pubmed
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pubmed-article:3403869pubmed:pagination287-90lld:pubmed
pubmed-article:3403869pubmed:dateRevised2004-11-17lld:pubmed
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pubmed-article:3403869pubmed:year1988lld:pubmed
pubmed-article:3403869pubmed:articleTitleLate systemic-allergic reactions to inhalant allergen immunotherapy.lld:pubmed
pubmed-article:3403869pubmed:affiliationAllergy and Immunization Clinic, Womack Army Community Hospital, Fort Bragg, N.C.lld:pubmed
pubmed-article:3403869pubmed:publicationTypeJournal Articlelld:pubmed