Linked Life Data

3392662

Source:http://linkedlifedata.com/resource/pubmed/id/3392662

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1988-8-17
pubmed:abstractText
Assays of neuron-localized (neurotypic) and glia-localized (gliotypic) proteins were used to detect and characterize the toxic effects of tributyltin (TBT) on the developing rat central nervous system. Four proteins associated with specific aspects of neuronal and glial development were evaluated: 1) p38, a synaptic vesicle-associated protein; 2) neurofilament 200, an intermediate filament protein of the neuronal cytoskeleton; 3) myelin basic protein, an oligodendroglia and myelin-sheath associated protein; and 4) glial fibrillary acidic protein, an intermediate filament protein of astrocytes. On postnatal days 13, 22 and 60, the amount of each protein in homogenates of cerebellum, forebrain and hippocampus was determined by radioimmunoassay. A single administration of TBT (2, 3 or 4 mg/kg i.p.) on postnatal day 5 caused dose- and region-dependent decreases in brain weight with the cerebellum being most affected. These decrements were not associated with light microscopic evidence of altered brain development (on postnatal day 61) but were accompanied by large dose- and region-dependent decreases in p38 and myelin basic protein. Decrements in both the per tissue (total) and per milligram of tissue protein (concentration) values for these proteins were observed in cerebellum and forebrain; hippocampus was largely unaffected. TBT-induced reductions in p38 and myelin basic protein were seen at dosages that did not affect brain, thymus or body weight. At dosages of TBT that did not affect body weight, reductions in brain weight, p 38 and myelin basic protein did not persist into adulthood. The data indicate that exposure to TBT on postnatal day 5 is toxic to the developing nervous system.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0022-3565
pubmed:author
pubmed:issnType
Print
pubmed:volume
246
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
394-402
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Acute exposure of the neonatal rat to tributyltin results in decreases in biochemical indicators of synaptogenesis and myelinogenesis.
pubmed:affiliation
Neurotoxicology Division, Environmental Protection Agency, Research Triangle Park, North Carolina.
pubmed:publicationType
Journal Article