Linked Life Data

3384161

Source:http://linkedlifedata.com/resource/pubmed/id/3384161

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-7-29
pubmed:abstractText
In order to study the effects of sex hormones administered during the neonatal period on the thymic development we have injected 5 days old female rats with a single dose (0.1mg) of estradiol benzoate. The evolution of the thymus gland after treatment was morphometrically analyzed. The thymus of the estrogen-injected animals diminished in size between the 7th and the 15th day, increasing afterwards. The cortex was the most sensitive compartment in the thymus to estrogenic treatment. Both thymic involution and enlargement were associated to changes in the frequency of large lymphoid cells in the subcapsular region and variations in the thymic cortex weights. The observed effects are tentatively attributed to alterations in the thymocyte differentiation probably due to modifications in the secretion of thymic hormones.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0145-305X
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-83
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effects of neonatal treatment with estrogens on the development of the thymus in rats.
pubmed:affiliation
Depto de Biología Celular, Facultad de C. Biológicas, Universidad Complutense de Madrid, Spain.
pubmed:publicationType
Journal Article