Linked Life Data

3384031

Source:http://linkedlifedata.com/resource/pubmed/id/3384031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-7-29
pubmed:abstractText
Averaged evoked potentials from primary somatosensory cortex (SEPs) were recorded before and after pairing the peripheral stimuli with electrical activation of the basal forebrain (BF) in anesthetized cats. Four pulses at 400 Hz were delivered to the BF 120 ms before each cutaneous stimulus and 10 to 660 such pairings were found to produce an enlargement of the SEP in 10 of 11 animals. The average increase in amplitude of the initial peak of the SEP was 69%. The SEP remained enhanced in five of six animals that were tested an hour or more after the pairing, and in one case the SEP was tested 4.5 h after pairing without diminution. The effective BF sites were located in the substantia innominata and at the rostral pole of the globus pallidus, regions known to contain many cholinergic cell bodies. Enhancement occurred consistently only if stimulation of the BF site elicited a positive wave in the cortex at a latency of 11 to 18 ms. Repeated BF stimulation without cutaneous input did not produce a change in subsequent SEPs. The long-term changes described here may be involved in experimentally- and naturally-induced cortical reorganization.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0014-4819
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
276-86
pubmed:dateRevised
2009-11-11
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Long-term enhancement of evoked potentials in cat somatosensory cortex produced by co-activation of the basal forebrain and cutaneous receptors.
pubmed:affiliation
Department of Physiology and Biophysics, Dalhousie University, Halifax, Nova Scotia, Canada.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't