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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1988-8-1
|
| pubmed:abstractText |
Sotalol is a non-selective beta-adrenergic blocking agent with class III antiarrhythmic properties. Our study was intended to assess the efficacy of sotalol on exercise-inducible arrhythmias by oral administration to out patients. Thirty patients with exercise-inducible arrhythmias (80% coronary artery disease, 20% congestive cardiomyopathy) were studied after two baseline bicycle ergometric stress tests performed in upright position. Twenty-five patients (including nine crossover cases of the lower dose protocol) were given sotalol in a daily dose of 320 mg (group 1) and 14 patients in a dose of 160 mg (group 2). After 2 and 8 weeks, respectively, group 1 showed a mean reduction of the total number of inducible ventricular premature beats (VPBs) of 50% (P = 0.0042) and 61% (P = 0.0107), respectively and a significantly improved Lown score (P = 0.0002 and 0.0006, respectively). A significant antiarrhythmic response was not demonstrable for group-2 patients. Because of inefficacy, nine patients were changed from group 2 to group 1. Reduction of arrhythmias on the higher dose was significant (P = 0.0147) in this group. There was the same significant reduction of the heart rate pressure product with the low and high dosage indicating that the beta-blocker effect is achieved with the lower dosage. We conclude that sotalol is a powerful drug for reducing the number and complexity of ventricular arrhythmias in a dose of 320 mg daily. As the beta-blocking effect in both groups was the same, we assume that the reduction of arrhythmias is mainly due to class III action.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0195-668X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
9
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
265-70
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:3383867-Adolescent,
pubmed-meshheading:3383867-Adult,
pubmed-meshheading:3383867-Aged,
pubmed-meshheading:3383867-Arrhythmias, Cardiac,
pubmed-meshheading:3383867-Blood Pressure,
pubmed-meshheading:3383867-Cardiomyopathies,
pubmed-meshheading:3383867-Coronary Disease,
pubmed-meshheading:3383867-Dose-Response Relationship, Drug,
pubmed-meshheading:3383867-Electrocardiography,
pubmed-meshheading:3383867-Exercise Test,
pubmed-meshheading:3383867-Female,
pubmed-meshheading:3383867-Heart Rate,
pubmed-meshheading:3383867-Humans,
pubmed-meshheading:3383867-Male,
pubmed-meshheading:3383867-Middle Aged,
pubmed-meshheading:3383867-Sotalol
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
The effect of sotalol on exercise-induced ventricular arrhythmias.
|
| pubmed:affiliation |
University of Vienna, Clinic of Cardiology, Austria.
|
| pubmed:publicationType |
Journal Article
|