Linked Life Data

3376842

Source:http://linkedlifedata.com/resource/pubmed/id/3376842

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1988-6-28
pubmed:abstractText
Beta blockade may adversely affect inotropic state of the ventricle, resulting in exacerbation of congestive heart failure in subjects with reduced ventricular function. In normal subjects, ventricular contractility appears to be preserved following administration of beta blockers with intrinsic sympathomimetic activity (ISA). The inotropic state of the ventricle was assessed in seven subjects with congestive heart failure (mean ejection fraction = 23 +/- 5%) before and after administration of the ISA beta blocker, pindolol, with the use of the noninvasively derived end-systolic pressure/end-systolic dimension (ESP/ESD) relation. The mean slope of the ESP/ESD relation was 36.3 +/- 20.4 mm Hg/cm at baseline and increased to 45.0 +/- 25.2 mm Hg/cm following five consecutive 10 mg oral doses of pindolol (p = ns). Other simultaneously derived inotropic indices that included percent fractional shortening, mean delta P/delta T, velocity of circumferential fiber shortening, and preejection period-to-left ventricular ejection time ratio showed directionally similar changes toward a mild increase in contractility. These results indicate that the slope of the left ventricular ESP/ESD relation is not altered following repeated dosing with pindolol in subjects with congestive heart failure. This reflects a preservation of inotropic state following administration of this ISA beta blocker in a population with severely compromised ventricular function.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0002-8703
pubmed:author
pubmed:issnType
Print
pubmed:volume
115
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1245-50
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Preservation of the end-systolic pressure/end-systolic dimension relation following pindolol in congestive heart failure.
pubmed:affiliation
Division of Cardiology, Ohio State University, Columbus 43210.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't