Linked Life Data

3371404

Source:http://linkedlifedata.com/resource/pubmed/id/3371404

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2-3
pubmed:dateCreated
1988-7-12
pubmed:abstractText
Determination of the ED50s of glucose and fructose, administered i.p., for antagonizing the antinociceptive action of morphine (4 mg/kg s.c. or 0.5 micrograms i.t.) and determination of the ED50s for i.t. morphine after i.p. pretreatment with saline, glucose (5 g/kg) or fructose (5 g/kg) in the mouse tail-flick test indicated that fructose was more potent than glucose in antagonizing antinociception after either route or morphine administration. It is concluded that the antagonism of morphine-induced antinociception by glucose and fructose is due to a direct effect of these sugars or their metabolic products within the central nervous system.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0014-2999
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
146
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
337-40
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Antagonism of antinociception in mice by glucose and fructose: comparison of subcutaneous and intrathecal morphine.
pubmed:affiliation
Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0001.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.