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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1988-5-26
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pubmed:abstractText |
Theiler's virus, a murine picornavirus, causes a chronic neurological disease characterized by primary demyelination in SJL/J mice. The lesions are very reminiscent of those of multiple sclerosis. Theiler's virus persists in oligodendrocytes and to a lesser extent in astrocytes and macrophages throughout the disease. Viral RNA and capsid protein syntheses are minimal in these cells. This restriction could play a central role in the mechanism of virus persistence. By quantitating plus- and minus-strand RNAs in infected central nervous system cells, we showed that RNA replication was blocked at the level of minus-strand RNA synthesis.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-164412,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-216014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-2417240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-2849023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-2985806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-3021989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-3023668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-3840619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-6091052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-6206496,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-6288719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-6550524,
http://linkedlifedata.com/resource/pubmed/commentcorrection/3357212-7096324
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-538X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
62
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1824-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1988
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pubmed:articleTitle |
Minus-strand RNA synthesis in the spinal cords of mice persistently infected with Theiler's virus.
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pubmed:affiliation |
Département de Virologie, Institut Pasteur, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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