pubmed-article:3356706 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:3356706 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
pubmed-article:3356706 | lifeskim:mentions | umls-concept:C0043343 | lld:lifeskim |
pubmed-article:3356706 | lifeskim:mentions | umls-concept:C0029045 | lld:lifeskim |
pubmed-article:3356706 | lifeskim:mentions | umls-concept:C0035696 | lld:lifeskim |
pubmed-article:3356706 | lifeskim:mentions | umls-concept:C1519618 | lld:lifeskim |
pubmed-article:3356706 | lifeskim:mentions | umls-concept:C1519249 | lld:lifeskim |
pubmed-article:3356706 | pubmed:issue | 12 | lld:pubmed |
pubmed-article:3356706 | pubmed:dateCreated | 1988-5-18 | lld:pubmed |
pubmed-article:3356706 | pubmed:abstractText | We investigated the effect of 3'-noncoding and poly(A) sequences on the translation and stability of membrane-bound mRNA (maize zein) and free mRNA (Xenopus beta-globin) by injecting SP6 transcripts into stage 6 Xenopus oocytes. With zein mRNA, the presence or absence of a 3'-noncoding or poly(A) sequence had little effect on mRNA stability over 24 h, and the 3'-noncoding sequence played essentially no role in mRNA translation. With short periods of incubation, e.g. 1-2 h, the presence or absence of a poly(A) tail also had little effect on zein mRNA translation; but after longer periods, translation of the poly(A-) mRNA was significantly reduced. A similar pattern of mRNA translation was observed for poly(A+) and poly(A-) Xenopus beta-globin mRNAs. These differences in translational efficiency correlated with the formation of maximally loaded polysomes (seven-eight ribosomes/mRNA) for the poly(A+) zein mRNA and a failure to form large polysomes with the poly(A-) zein mRNA. These results are consistent with a model in which the 3'-poly(A) sequence of mRNAs facilitates reinitiation of ribosomes during protein synthesis. | lld:pubmed |
pubmed-article:3356706 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3356706 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3356706 | pubmed:language | eng | lld:pubmed |
pubmed-article:3356706 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3356706 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:3356706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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pubmed-article:3356706 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:3356706 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:3356706 | pubmed:month | Apr | lld:pubmed |
pubmed-article:3356706 | pubmed:issn | 0021-9258 | lld:pubmed |
pubmed-article:3356706 | pubmed:author | pubmed-author:SmithL DLD | lld:pubmed |
pubmed-article:3356706 | pubmed:author | pubmed-author:LarkinsB ABA | lld:pubmed |
pubmed-article:3356706 | pubmed:author | pubmed-author:GaliliGG | lld:pubmed |
pubmed-article:3356706 | pubmed:author | pubmed-author:KawataE EEE | lld:pubmed |
pubmed-article:3356706 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:3356706 | pubmed:day | 25 | lld:pubmed |
pubmed-article:3356706 | pubmed:volume | 263 | lld:pubmed |
pubmed-article:3356706 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:3356706 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:3356706 | pubmed:pagination | 5764-70 | lld:pubmed |
pubmed-article:3356706 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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pubmed-article:3356706 | pubmed:meshHeading | pubmed-meshheading:3356706-... | lld:pubmed |
pubmed-article:3356706 | pubmed:year | 1988 | lld:pubmed |
pubmed-article:3356706 | pubmed:articleTitle | Role of the 3'-poly(A) sequence in translational regulation of mRNAs in Xenopus laevis oocytes. | lld:pubmed |
pubmed-article:3356706 | pubmed:affiliation | Department of Botany and Plant Pathology, Purdue University, West Lafayette, Indiana 47907. | lld:pubmed |
pubmed-article:3356706 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:3356706 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
pubmed-article:3356706 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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