Linked Life Data

3356314

Source:http://linkedlifedata.com/resource/pubmed/id/3356314

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1988-5-13
pubmed:abstractText
The pharmacokinetics of the trichothecene mycotoxin deoxynivalenol (DON) was investigated in swine following intravenous (0.30 mg, 0.35 microCi/kg) and intragastric (0.60 mg, 0.60 microCi/kg) administration of the 14C-labeled toxin. After iv dosing, plasma concentration data favored a three-compartment open model with half-life values for the rapid distribution (alpha), slower distribution (beta), and terminal elimination (gamma) phases of 5.8, 96.7, and 510.0 min, respectively. The apparent volume of distribution (V'd) was 1.34 liter/kg, the volume of the central compartment (Vc) was 0.166 liter/kg, and the plasma clearance was 1.81 ml/min/kg. DON was rapidly cleared essentially unchanged (greater than 95%), and was excreted primarily in urine (86-104%), with minor elimination in bile (3-5%). Following intragastric dosing DON was very rapidly absorbed, reaching near peak plasma levels within 15-30 min. Levels remained elevated (63-325 ng/ml) for approximately 9 hr, and began declining slowly (t1/2 beta = 7.1 hr) thereafter. The calculated systemic bioavailability (F) was between 48 and 65%, although urinary and biliary recoveries indicated marginally greater absorption actually occurred (54-85%). Overall, although DON was eliminated rapidly and completely within 24 hr following a single iv or intragastric dose, data suggest that residues may undergo temporary sequestration in a tissue depot.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0272-0590
pubmed:author
pubmed:issnType
Print
pubmed:volume
10
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
276-86
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Pharmacokinetic fate of 14C-labeled deoxynivalenol in swine.
pubmed:affiliation
Animal Research Centre, Agriculture Canada, Central Experimental Farm, Ottawa, Ontario.
pubmed:publicationType
Journal Article