| pubmed-article:3337461 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3337461 | lifeskim:mentions | umls-concept:C0273115 | lld:lifeskim |
| pubmed-article:3337461 | lifeskim:mentions | umls-concept:C0205470 | lld:lifeskim |
| pubmed-article:3337461 | lifeskim:mentions | umls-concept:C0077151 | lld:lifeskim |
| pubmed-article:3337461 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:3337461 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:3337461 | lifeskim:mentions | umls-concept:C0332120 | lld:lifeskim |
| pubmed-article:3337461 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3337461 | pubmed:dateCreated | 1988-2-10 | lld:pubmed |
| pubmed-article:3337461 | pubmed:abstractText | Trimellitic anhydride (TMA) is a chemical intermediate that has been shown to cause immunologically mediated respiratory syndromes in humans. We developed a rat model in which lung lesions accompanied by TMA-specific antibody resembled effects seen in humans. Two sets of experiments were undertaken to determine if TMA lung injury was primarily controlled by the immune system. Experiment 1: Rats were exposed to 95 micrograms/m3 of TMA 6 h/day, 5 days/wk for 2 wk during which time they received daily injections of either the immunosuppressant cyclophosphamide or saline. The TMA-exposed/saline control rats exhibited the usual TMA-induced lung lesions accompanied by TMA-specific antibody. However, the TMA-exposed/cyclophosphamide rats showed no lesions and no antibody. The spleen cells from all rats were subjected to lymphocyte blastogenesis assays using T- and B-cell mitogens. Results confirmed that cyclophosphamide-treated rats showed very little if any blastogenic response, whereas saline-treated rats gave the normal immune response. Thus, cyclophosphamide eliminated T- and B-cell function, which in turn prevented the occurrence of TMA lesions. Experiment 2: An initial passive transfer experiment showed that serum from TMA-sensitized rats could be adoptively transferred into naive recipient rats, which when given a single TMA inhalation challenge exhibited TMA-induced lesions. Similar attempts to transfer spleen cells or spleen cells plus serum did not predispose recipients for lesions. A second modified passive transfer of sensitized serum using a larger number of recipient rats, followed by a TMA challenge, resulted in lesions in 14 of the 16 rats.(ABSTRACT TRUNCATED AT 250 WORDS) | lld:pubmed |
| pubmed-article:3337461 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3337461 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337461 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:3337461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337461 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3337461 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3337461 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:3337461 | pubmed:issn | 0003-0805 | lld:pubmed |
| pubmed-article:3337461 | pubmed:author | pubmed-author:ZeissC RCR | lld:pubmed |
| pubmed-article:3337461 | pubmed:author | pubmed-author:HatoumN SNS | lld:pubmed |
| pubmed-article:3337461 | pubmed:author | pubmed-author:GarvinP JPJ | lld:pubmed |
| pubmed-article:3337461 | pubmed:author | pubmed-author:RatajczakH... | lld:pubmed |
| pubmed-article:3337461 | pubmed:author | pubmed-author:LeachC LCL | lld:pubmed |
| pubmed-article:3337461 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3337461 | pubmed:volume | 137 | lld:pubmed |
| pubmed-article:3337461 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3337461 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3337461 | pubmed:pagination | 186-90 | lld:pubmed |
| pubmed-article:3337461 | pubmed:dateRevised | 2003-11-14 | lld:pubmed |
| pubmed-article:3337461 | pubmed:meshHeading | pubmed-meshheading:3337461-... | lld:pubmed |
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| pubmed-article:3337461 | pubmed:meshHeading | pubmed-meshheading:3337461-... | lld:pubmed |
| pubmed-article:3337461 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3337461 | pubmed:articleTitle | Evidence of immunologic control of lung injury induced by trimellitic anhydride. | lld:pubmed |
| pubmed-article:3337461 | pubmed:affiliation | IIT Research Institute, Veterans Administration Lakeside Medical Center, Chicago, IL 60616. | lld:pubmed |
| pubmed-article:3337461 | pubmed:publicationType | Journal Article | lld:pubmed |
