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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1988-2-10
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pubmed:abstractText |
Trimellitic anhydride (TMA) is a chemical intermediate that has been shown to cause immunologically mediated respiratory syndromes in humans. We developed a rat model in which lung lesions accompanied by TMA-specific antibody resembled effects seen in humans. Two sets of experiments were undertaken to determine if TMA lung injury was primarily controlled by the immune system. Experiment 1: Rats were exposed to 95 micrograms/m3 of TMA 6 h/day, 5 days/wk for 2 wk during which time they received daily injections of either the immunosuppressant cyclophosphamide or saline. The TMA-exposed/saline control rats exhibited the usual TMA-induced lung lesions accompanied by TMA-specific antibody. However, the TMA-exposed/cyclophosphamide rats showed no lesions and no antibody. The spleen cells from all rats were subjected to lymphocyte blastogenesis assays using T- and B-cell mitogens. Results confirmed that cyclophosphamide-treated rats showed very little if any blastogenic response, whereas saline-treated rats gave the normal immune response. Thus, cyclophosphamide eliminated T- and B-cell function, which in turn prevented the occurrence of TMA lesions. Experiment 2: An initial passive transfer experiment showed that serum from TMA-sensitized rats could be adoptively transferred into naive recipient rats, which when given a single TMA inhalation challenge exhibited TMA-induced lesions. Similar attempts to transfer spleen cells or spleen cells plus serum did not predispose recipients for lesions. A second modified passive transfer of sensitized serum using a larger number of recipient rats, followed by a TMA challenge, resulted in lesions in 14 of the 16 rats.(ABSTRACT TRUNCATED AT 250 WORDS)
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclophosphamide,
http://linkedlifedata.com/resource/pubmed/chemical/Phthalic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Phthalic Anhydrides,
http://linkedlifedata.com/resource/pubmed/chemical/trimellitic anhydride
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0003-0805
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
137
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
186-90
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pubmed:dateRevised |
2003-11-14
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pubmed:meshHeading |
pubmed-meshheading:3337461-Animals,
pubmed-meshheading:3337461-Antibodies,
pubmed-meshheading:3337461-Cyclophosphamide,
pubmed-meshheading:3337461-Immunization, Passive,
pubmed-meshheading:3337461-Immunosuppression,
pubmed-meshheading:3337461-Lung,
pubmed-meshheading:3337461-Lung Diseases,
pubmed-meshheading:3337461-Lymphocyte Activation,
pubmed-meshheading:3337461-Male,
pubmed-meshheading:3337461-Phthalic Acids,
pubmed-meshheading:3337461-Phthalic Anhydrides,
pubmed-meshheading:3337461-Rats,
pubmed-meshheading:3337461-Rats, Inbred Strains
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pubmed:year |
1988
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pubmed:articleTitle |
Evidence of immunologic control of lung injury induced by trimellitic anhydride.
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pubmed:affiliation |
IIT Research Institute, Veterans Administration Lakeside Medical Center, Chicago, IL 60616.
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pubmed:publicationType |
Journal Article
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