| pubmed-article:3332118 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3332118 | lifeskim:mentions | umls-concept:C0023418 | lld:lifeskim |
| pubmed-article:3332118 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:3332118 | lifeskim:mentions | umls-concept:C0149615 | lld:lifeskim |
| pubmed-article:3332118 | lifeskim:mentions | umls-concept:C0376152 | lld:lifeskim |
| pubmed-article:3332118 | lifeskim:mentions | umls-concept:C1979893 | lld:lifeskim |
| pubmed-article:3332118 | lifeskim:mentions | umls-concept:C0283960 | lld:lifeskim |
| pubmed-article:3332118 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3332118 | pubmed:dateCreated | 1988-11-15 | lld:pubmed |
| pubmed-article:3332118 | pubmed:abstractText | A heterogeneous group of 11 consecutive patients with leukaemia have been transplanted successfully with allogeneic marrow depleted of T lymphocytes by soy bean lectin agglutination and neuraminidase-treated sheep erythrocyte rosetting. Effective depletion was achieved, leaving less than 1% of donor T lymphocytes. Despite the small numbers of nucleated cells infused (mean 0.14 X 10(8)/kg) there was only moderately delayed recovery of peripheral blood counts and no graft failures have occurred. Standard methotrexate prophylaxis against graft-versus-host disease (GVHD) was also employed in the first four transplants. Only one case of mild grade I (skin only) acute GVHD has occurred and there has been no chronic GVHD to date. The group of patients show an actuarial cumulative survival of 55% with two early infective deaths (days 42 and 44 post-transplant) and three late deaths, two with leukaemic relapse and the third with probable viral encephalitis. The longest survivor is now 1109 days post-transplant. This series indicates that lectin fractionation of donor marrow, previously employed mainly in children, can also be effective in minimizing GVHD in adults without endangering successful engraftment. | lld:pubmed |
| pubmed-article:3332118 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3332118 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3332118 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3332118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3332118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3332118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3332118 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3332118 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3332118 | pubmed:month | May | lld:pubmed |
| pubmed-article:3332118 | pubmed:issn | 0268-3369 | lld:pubmed |
| pubmed-article:3332118 | pubmed:author | pubmed-author:JonesH MHM | lld:pubmed |
| pubmed-article:3332118 | pubmed:author | pubmed-author:NewlandA CAC | lld:pubmed |
| pubmed-article:3332118 | pubmed:author | pubmed-author:SlocombeG WGW | lld:pubmed |
| pubmed-article:3332118 | pubmed:author | pubmed-author:MaceyMM | lld:pubmed |
| pubmed-article:3332118 | pubmed:author | pubmed-author:KnottLL | lld:pubmed |
| pubmed-article:3332118 | pubmed:author | pubmed-author:YeatmanN WNW | lld:pubmed |
| pubmed-article:3332118 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3332118 | pubmed:volume | 1 | lld:pubmed |
| pubmed-article:3332118 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3332118 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3332118 | pubmed:pagination | 31-9 | lld:pubmed |
| pubmed-article:3332118 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
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| pubmed-article:3332118 | pubmed:meshHeading | pubmed-meshheading:3332118-... | lld:pubmed |
| pubmed-article:3332118 | pubmed:meshHeading | pubmed-meshheading:3332118-... | lld:pubmed |
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| pubmed-article:3332118 | pubmed:meshHeading | pubmed-meshheading:3332118-... | lld:pubmed |
| pubmed-article:3332118 | pubmed:year | 1986 | lld:pubmed |
| pubmed-article:3332118 | pubmed:articleTitle | Allogeneic bone marrow transplantation for adult leukaemia with soy bean lectin fractionated marrow. | lld:pubmed |
| pubmed-article:3332118 | pubmed:affiliation | Department of Haematology, London Hospital, UK. | lld:pubmed |
| pubmed-article:3332118 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:3332118 | lld:pubmed |
