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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1988-11-15
|
| pubmed:abstractText |
A heterogeneous group of 11 consecutive patients with leukaemia have been transplanted successfully with allogeneic marrow depleted of T lymphocytes by soy bean lectin agglutination and neuraminidase-treated sheep erythrocyte rosetting. Effective depletion was achieved, leaving less than 1% of donor T lymphocytes. Despite the small numbers of nucleated cells infused (mean 0.14 X 10(8)/kg) there was only moderately delayed recovery of peripheral blood counts and no graft failures have occurred. Standard methotrexate prophylaxis against graft-versus-host disease (GVHD) was also employed in the first four transplants. Only one case of mild grade I (skin only) acute GVHD has occurred and there has been no chronic GVHD to date. The group of patients show an actuarial cumulative survival of 55% with two early infective deaths (days 42 and 44 post-transplant) and three late deaths, two with leukaemic relapse and the third with probable viral encephalitis. The longest survivor is now 1109 days post-transplant. This series indicates that lectin fractionation of donor marrow, previously employed mainly in children, can also be effective in minimizing GVHD in adults without endangering successful engraftment.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0268-3369
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
1
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
31-9
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:3332118-Adolescent,
pubmed-meshheading:3332118-Adult,
pubmed-meshheading:3332118-Bone Marrow Transplantation,
pubmed-meshheading:3332118-Cell Count,
pubmed-meshheading:3332118-Child,
pubmed-meshheading:3332118-Female,
pubmed-meshheading:3332118-Graft vs Host Disease,
pubmed-meshheading:3332118-Humans,
pubmed-meshheading:3332118-Infection,
pubmed-meshheading:3332118-Lectins,
pubmed-meshheading:3332118-Leukemia,
pubmed-meshheading:3332118-Lymphocyte Depletion,
pubmed-meshheading:3332118-Male,
pubmed-meshheading:3332118-Middle Aged,
pubmed-meshheading:3332118-Plant Lectins,
pubmed-meshheading:3332118-Recurrence,
pubmed-meshheading:3332118-Soybean Proteins,
pubmed-meshheading:3332118-Soybeans,
pubmed-meshheading:3332118-T-Lymphocytes
|
| pubmed:year |
1986
|
| pubmed:articleTitle |
Allogeneic bone marrow transplantation for adult leukaemia with soy bean lectin fractionated marrow.
|
| pubmed:affiliation |
Department of Haematology, London Hospital, UK.
|
| pubmed:publicationType |
Journal Article
|