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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11
|
pubmed:dateCreated |
1988-4-21
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pubmed:abstractText |
Five normal non-smoking subjects inhaled an aerosol of 99Tcm-DTPA in saline with a mass median aerodynamic diameter of 0.6 micron. The rate of clearance (k) of the inhaled 99Tcm-DTPA from lung to blood was measured using a gamma scintillation camera with computer data acquisition. During a single clearance study the subjects voluntarily breathed close to total lung capacity (TLC) and close to residual volume (RV). They breathed at one volume for 5 min, then at the opposite volume for 5 min and finally reverted to the original volume for 5 min with a 1 min pause between each manoeuvre. The order in which each subject performed these breathing patterns was randomized. Tidal volume, respiratory frequency and end expired volume were measured with a water spirometer. When they breathed close to TLC the rate of clearance increased (k = 4.62 +/- 1.03%/min) compared with breathing close to RV (k = 1.96 +/- 0.5%/min). This effect of changing volume was immediately reversible after adopting each new lung volume. There were no significant changes in tidal volume or respiratory frequency between each 5 min period. There was no significant difference between the clearance increased (k = 4.62 +/- 1.03%/min) compared with breathing close to RV (k = 1.96 +/- 0.5%/min). This effect of changing volume was immediately reversible after adopting immediate and reversible.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0143-3636
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pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
8
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
881-7
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:3327018-Administration, Inhalation,
pubmed-meshheading:3327018-Adult,
pubmed-meshheading:3327018-Humans,
pubmed-meshheading:3327018-Lung Volume Measurements,
pubmed-meshheading:3327018-Male,
pubmed-meshheading:3327018-Metabolic Clearance Rate,
pubmed-meshheading:3327018-Middle Aged,
pubmed-meshheading:3327018-Organometallic Compounds,
pubmed-meshheading:3327018-Pentetic Acid,
pubmed-meshheading:3327018-Technetium,
pubmed-meshheading:3327018-Technetium Tc 99m Pentetate
|
pubmed:year |
1987
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pubmed:articleTitle |
The rapid reversibility of effects of changing lung volume on the clearance rate of inhaled 99Tcm-DTPA in man.
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pubmed:affiliation |
Department of Respiratory Physiology, Addenbrooke's Hospital, Cambridge, UK.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial
|