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pubmed-article:3317828pubmed:abstractTextImmunotoxins are conjugates of cell-reactive antibodies and toxins or their subunits. In this report, the chemistry, biology, pharmacokinetics, and anti-tumor effects of first generation immunotoxins; the preparation of improved second generation immunotoxins that display greater anti-tumor efficacy; and the role of genetic engineering in creating third-generation immunotoxins are discussed.lld:pubmed
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pubmed-article:3317828pubmed:articleTitleRedesigning nature's poisons to create anti-tumor reagents.lld:pubmed
pubmed-article:3317828pubmed:affiliationDepartment of Microbiology, University of Texas Southwestern Medical Center, Dallas 75235.lld:pubmed
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