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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1988-1-6
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pubmed:abstractText |
Salmonella typhimurium SR-11 mutants with cya::Tn10 or crp::Tn10 mutations were found to be avirulent and immunogenic for BALB/c mice. Fusaric acid-resistant derivatives with deletions of the Tn10 and adjacent DNA sequences were constructed in S. typhimurium SR-11 strains with or without the virulence plasmid pStSR100. These delta cya delta crp strains grew more slowly than wild-type strains. They possessed wild-type ability to attach to, invade, and persist in gut-associated lymphoid tissue for up to a week but exhibited a diminished ability to reach mesenteric lymph nodes and the spleen. Mice 4 to 8 weeks old were resistant to oral infection with 10(9) cells of several different delta cya and delta cya delta crp strains (the equivalent to 10(4) 50% lethal doses of wild-type S. typhimurium SR-11) and 30 days after immunization became resistant to oral challenge with 10(3) to 10(4) 50% lethal doses of wild-type S. typhimurium SR-11.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/3316029-1092768,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/3316029-925379
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
55
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3035-43
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:3316029-Adenylate Cyclase,
pubmed-meshheading:3316029-Administration, Oral,
pubmed-meshheading:3316029-Animals,
pubmed-meshheading:3316029-Immunization,
pubmed-meshheading:3316029-Lymph Nodes,
pubmed-meshheading:3316029-Mice,
pubmed-meshheading:3316029-Mutation,
pubmed-meshheading:3316029-Peyer's Patches,
pubmed-meshheading:3316029-Receptors, Cyclic AMP,
pubmed-meshheading:3316029-Salmonella Infections, Animal,
pubmed-meshheading:3316029-Salmonella typhimurium,
pubmed-meshheading:3316029-Tissue Distribution
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pubmed:year |
1987
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pubmed:articleTitle |
Salmonella typhimurium deletion mutants lacking adenylate cyclase and cyclic AMP receptor protein are avirulent and immunogenic.
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pubmed:affiliation |
Department of Biology, Washington University, St. Louis, Missouri 63130.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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