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| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C0032659 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C0334094 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C0457784 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C1521721 | lld:lifeskim |
| pubmed-article:3311498 | lifeskim:mentions | umls-concept:C1291775 | lld:lifeskim |
| pubmed-article:3311498 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3311498 | pubmed:dateCreated | 1987-12-14 | lld:pubmed |
| pubmed-article:3311498 | pubmed:abstractText | The efficacy of dendritic cells in antigen presentation was studied in eight healthy subjects using a lymphoproliferation assay. Both particulate (Mycobacterium leprae, H37Ra) and soluble (PPD, tetanus toxoid) bacterial antigens were used as stimulants over a concentration range of accessory cells (monocytes (MO) and dendritic cells (DC)) varying from 10 to 0.1% in co-cultures using T-enriched cells. In general, co-cultures with T + MO and T + DC at all concentrations of accessory cells showed significant improvement of antigen-induced lymphoproliferation over PBMC cultures. The improvement in delta ct/min of T + DC co-cultures as compared to T + MO with parallel concentrations of accessory cells (P less than 0.05 to less than 0.01) was significant. Of the bacterial antigens used to test the antigen-presenting ability of DC, the particulate antigen (H37Ra) showed the most impressive improvement (380%) of T cell proliferation in DC reconstituted cultures as compared to monocytes. PPD, soluble protein derived from a similar tuberculosis strain of mycobacteria, was not presented as effectively as the particulate equivalent even though the donors of the appropriate cell combinations showed skin test reactivity to this antigen. | lld:pubmed |
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| pubmed-article:3311498 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3311498 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3311498 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3311498 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:3311498 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3311498 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:3311498 | pubmed:issn | 0009-9104 | lld:pubmed |
| pubmed-article:3311498 | pubmed:author | pubmed-author:NathII | lld:pubmed |
| pubmed-article:3311498 | pubmed:author | pubmed-author:MittalAA | lld:pubmed |
| pubmed-article:3311498 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3311498 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:3311498 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3311498 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3311498 | pubmed:pagination | 611-7 | lld:pubmed |
| pubmed-article:3311498 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3311498 | pubmed:meshHeading | pubmed-meshheading:3311498-... | lld:pubmed |
| pubmed-article:3311498 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3311498 | pubmed:articleTitle | Human T cell proliferative responses to particulate microbial antigens are supported by populations enriched in dendritic cells. | lld:pubmed |
| pubmed-article:3311498 | pubmed:affiliation | Department of Pathology, All India Institute of Medical Sciences, New Delhi. | lld:pubmed |
| pubmed-article:3311498 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3311498 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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