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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1987-12-14
|
| pubmed:abstractText |
The results presented in this paper demonstrate that recombinant human granulocyte-colony stimulating factor (rhG-CSF) is a potent myelopoietic growth and differentiation factor in vivo. RhG-CSF was able to shorten the time period of neutrophil recovery in both cyclophosphamide (CY)-induced myelosuppression and following bone marrow transplantation (BMT) in primates. Its ability to significantly shorten the period of chemotherapy-induced bone marrow hypoplasia may allow clinicians to increase the frequency or dosage of chemotherapeutic agents. In addition, the increase in absolute numbers of functionally active neutrophils may have a profound effect on the rate and severity of neutropenia-related sepsis. Furthermore, the activities reported here indicate a potential role for rhG-CSF in the treatment of patients with myelodysplastic syndrome, congenital agranulocytosis, radiation-induced myelosuppression, and after bone marrow transplantation.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0340-4684
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
13
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
17-30
|
| pubmed:dateRevised |
2007-11-14
|
| pubmed:meshHeading |
pubmed-meshheading:3311216-Animals,
pubmed-meshheading:3311216-Bone Marrow,
pubmed-meshheading:3311216-Bone Marrow Cells,
pubmed-meshheading:3311216-Bone Marrow Diseases,
pubmed-meshheading:3311216-Bone Marrow Transplantation,
pubmed-meshheading:3311216-Cell Differentiation,
pubmed-meshheading:3311216-Colony-Stimulating Factors,
pubmed-meshheading:3311216-Cyclophosphamide,
pubmed-meshheading:3311216-Hematopoiesis,
pubmed-meshheading:3311216-Hematopoiesis, Extramedullary,
pubmed-meshheading:3311216-Hematopoietic Stem Cells,
pubmed-meshheading:3311216-Humans,
pubmed-meshheading:3311216-Leukemia, Experimental,
pubmed-meshheading:3311216-Macaca fascicularis,
pubmed-meshheading:3311216-Mice,
pubmed-meshheading:3311216-Neutrophils,
pubmed-meshheading:3311216-Recombinant Proteins,
pubmed-meshheading:3311216-Transplantation, Autologous,
pubmed-meshheading:3311216-Tumor Cells, Cultured
|
| pubmed:year |
1987
|
| pubmed:articleTitle |
Recombinant human granulocyte-colony stimulating factor: in vitro and in vivo effects on myelopoiesis.
|
| pubmed:affiliation |
Laboratory of Cytokine Biology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|