Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1977-10-28
pubmed:abstractText
2-Deaminoactinomycin D has been synthesized and characterized. It binds to DNA by intercalation according to NMR, CD, thermal denaturation, and unwinding studies on the drug-DNA complex. Loss of the 2-amino group does not seriously affect binding parameters relative to actinomycin D; affinity for calf thymus DNA may even be increased, according to deltaTm measurements. The unwinding of circular DNA caused by this compound is at least as large as that effected by actinomycin D and ethidium bromide. Nevertheless, 2-deaminoactinomycin D is less effective than actinomycin D in inhibiting nucleic acid syntheses in L1210 cell culture and in in vivo antitumor activity against P388 leukemia.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0022-2623
pubmed:author
pubmed:issnType
Print
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1055-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:330857-Animals, pubmed-meshheading:330857-Antineoplastic Agents, pubmed-meshheading:330857-Cells, Cultured, pubmed-meshheading:330857-Circular Dichroism, pubmed-meshheading:330857-DNA, pubmed-meshheading:330857-DNA, Bacterial, pubmed-meshheading:330857-DNA, Circular, pubmed-meshheading:330857-DNA, Neoplasm, pubmed-meshheading:330857-Dactinomycin, pubmed-meshheading:330857-Deamination, pubmed-meshheading:330857-Depression, Chemical, pubmed-meshheading:330857-Escherichia coli, pubmed-meshheading:330857-Leukemia, Experimental, pubmed-meshheading:330857-Leukemia L1210, pubmed-meshheading:330857-Magnetic Resonance Spectroscopy, pubmed-meshheading:330857-Mice, pubmed-meshheading:330857-Nucleic Acid Conformation, pubmed-meshheading:330857-Nucleic Acid Denaturation, pubmed-meshheading:330857-RNA, Neoplasm
pubmed:year
1977
pubmed:articleTitle
2-Deaminoactinomycin D, synthesis and interaction with deoxyribonucleic acid.
pubmed:publicationType
Journal Article, In Vitro, Research Support, U.S. Gov't, P.H.S.