|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
1977-10-31
|
|
pubmed:abstractText |
Further studies are presented on the intracellular localization of the amyloid-related serum protein SAA previously shown to be produced by embryonal fibroblasts. In cultured embryonal fibroblasts, the fine fibrillar cytoplasmic immunofluorescence obtained by anti-SAA was distinguished from that of microfilaments and microtubules. By using electron microscopy and cells treated with drugs known to specifically alter intracellular fibrils, SAA was localized to 10-nm intermediate size filaments. These filaments form characteristic perinuclear bundles upon treatment with drugs such as demecolcine or vinblastine which disrupt micotubules. The results indicate that SAA is a constituent of the intracellular cytoskeleton.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-1025153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-322137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-4205522,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-47333,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-52891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-54920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-561084,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-5812469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-792382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-804694,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-887156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/330793-945140
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Oct
|
|
pubmed:issn |
0022-1007
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
146
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1158-63
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
1977
|
|
pubmed:articleTitle |
Localization of amyloid-related serum protein SAA-like material to intermediate (10 nm) filaments of cultured human embryonal fibroblasts.
|
|
pubmed:publicationType |
Journal Article
|
