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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1987-8-25
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pubmed:abstractText |
Betaxolol, a beta 1-selective adrenergic antagonist, and nadolol, a nonselective beta-adrenergic antagonist are both potent long-acting antihypertensive drugs. The effects of betaxolol on renal function have not been reported. The effects of nadolol on renal function are controversial. The current randomized double-blind study was designed to compare the effects of betaxolol and nadolol on glomerular filtration rate, assessed by creatinine and inulin clearances, and renal hemodynamics, assessed by p-aminohippurate clearance. Following a 4-week placebo run-in period, 15 patients with essential hypertension were randomized to a mean dose of 22 mg betaxolol for 12 weeks, and 12 patients with essential hypertension were randomized to a mean dose of 103 mg nadolol for 12 weeks. Results indicate that neither drug produced a clinically relevant effect on renal function. These findings are consistent with previously reported observations with other beta-adrenergic blocking drugs. We conclude that neither of the beta-adrenergic antagonists, betaxolol or nadolol, convey a specific renal pharmacologic advantage; both are equally efficacious and safe in the treatment of mild-to-moderate essential hypertension.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0272-6386
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
109-12
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:3300292-Betaxolol,
pubmed-meshheading:3300292-Blood Pressure,
pubmed-meshheading:3300292-Body Weight,
pubmed-meshheading:3300292-Clinical Trials as Topic,
pubmed-meshheading:3300292-Double-Blind Method,
pubmed-meshheading:3300292-Humans,
pubmed-meshheading:3300292-Hypertension,
pubmed-meshheading:3300292-Kidney,
pubmed-meshheading:3300292-Kidney Function Tests,
pubmed-meshheading:3300292-Male,
pubmed-meshheading:3300292-Middle Aged,
pubmed-meshheading:3300292-Nadolol,
pubmed-meshheading:3300292-Propanolamines,
pubmed-meshheading:3300292-Pulse,
pubmed-meshheading:3300292-Random Allocation,
pubmed-meshheading:3300292-Sodium
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pubmed:year |
1987
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pubmed:articleTitle |
A comparison of betaxolol and nadolol on renal function in essential hypertension.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial
|