| pubmed-article:3295317 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3295317 | lifeskim:mentions | umls-concept:C0376387 | lld:lifeskim |
| pubmed-article:3295317 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
| pubmed-article:3295317 | lifeskim:mentions | umls-concept:C0376152 | lld:lifeskim |
| pubmed-article:3295317 | lifeskim:mentions | umls-concept:C0002521 | lld:lifeskim |
| pubmed-article:3295317 | lifeskim:mentions | umls-concept:C0348016 | lld:lifeskim |
| pubmed-article:3295317 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:3295317 | pubmed:dateCreated | 1987-6-29 | lld:pubmed |
| pubmed-article:3295317 | pubmed:abstractText | Branched chain amino acids (BCAA) improve nitrogen balance and end-organ function in surgical patients, but are untested in marrow transplant recipients. We compared nitrogen balance, urinary 3-methylhistidine-to-creatinine ratio, upper arm anthropometry, serum prealbumin, and day to peripheral engraftment in a randomized, double-blinded trial between 45% (high-leucine) and 23% BCAA intravenous solutions in 40 adult leukemia patients for 1 month following allogeneic marrow transplantation. Nutritional support, provided at approximately 30 nonprotein calories/kg and 0.21 g nitrogen/kg ideal weight, did not differ between groups. Despite greater nitrogen loss and muscle breakdown evidenced by increased 3-methylhistidine-to-creatinine ratio and loss of arm muscle area by study end in the 45% BCAA, no statistical differences were observed when nitrogen balance was compared by week and within stress level as defined by organ and infectious complications. It is likely the patients in the 45% BCAA experienced greater metabolic stress by study end. Serum prealbumin and day posttransplant to peripheral engraftment also did not differ between groups. The chances (power) of this study exceeded 85% in detecting a difference in nitrogen balance of 2.5 g during study week 1 and 4.0 g during week 2. The power during week 3 was 77% for detecting a difference of 4.0 g, and it is unlikely that the true difference exceeds this magnitude. Thus, we did not find any evidence that intravenous BCAA-enriched solutions improved nitrogen balance during the first month after marrow transplantation. | lld:pubmed |
| pubmed-article:3295317 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3295317 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3295317 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3295317 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3295317 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3295317 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3295317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3295317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3295317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3295317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3295317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3295317 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3295317 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3295317 | pubmed:issn | 0148-6071 | lld:pubmed |
| pubmed-article:3295317 | pubmed:author | pubmed-author:CunninghamB... | lld:pubmed |
| pubmed-article:3295317 | pubmed:author | pubmed-author:AkerS NSN | lld:pubmed |
| pubmed-article:3295317 | pubmed:author | pubmed-author:CheneyC LCL | lld:pubmed |
| pubmed-article:3295317 | pubmed:author | pubmed-author:LenssenPP | lld:pubmed |
| pubmed-article:3295317 | pubmed:author | pubmed-author:GauvreauJ MJM | lld:pubmed |
| pubmed-article:3295317 | pubmed:author | pubmed-author:BaraleK VKV | lld:pubmed |
| pubmed-article:3295317 | pubmed:author | pubmed-author:DarbinianJJ | lld:pubmed |
| pubmed-article:3295317 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3295317 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:3295317 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3295317 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3295317 | pubmed:pagination | 112-8 | lld:pubmed |
| pubmed-article:3295317 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:meshHeading | pubmed-meshheading:3295317-... | lld:pubmed |
| pubmed-article:3295317 | pubmed:articleTitle | Intravenous branched chain amino acid trial in marrow transplant recipients. | lld:pubmed |
| pubmed-article:3295317 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3295317 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:3295317 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:3295317 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:3295317 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
