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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1987-6-29
|
| pubmed:abstractText |
Branched chain amino acids (BCAA) improve nitrogen balance and end-organ function in surgical patients, but are untested in marrow transplant recipients. We compared nitrogen balance, urinary 3-methylhistidine-to-creatinine ratio, upper arm anthropometry, serum prealbumin, and day to peripheral engraftment in a randomized, double-blinded trial between 45% (high-leucine) and 23% BCAA intravenous solutions in 40 adult leukemia patients for 1 month following allogeneic marrow transplantation. Nutritional support, provided at approximately 30 nonprotein calories/kg and 0.21 g nitrogen/kg ideal weight, did not differ between groups. Despite greater nitrogen loss and muscle breakdown evidenced by increased 3-methylhistidine-to-creatinine ratio and loss of arm muscle area by study end in the 45% BCAA, no statistical differences were observed when nitrogen balance was compared by week and within stress level as defined by organ and infectious complications. It is likely the patients in the 45% BCAA experienced greater metabolic stress by study end. Serum prealbumin and day posttransplant to peripheral engraftment also did not differ between groups. The chances (power) of this study exceeded 85% in detecting a difference in nitrogen balance of 2.5 g during study week 1 and 4.0 g during week 2. The power during week 3 was 77% for detecting a difference of 4.0 g, and it is unlikely that the true difference exceeds this magnitude. Thus, we did not find any evidence that intravenous BCAA-enriched solutions improved nitrogen balance during the first month after marrow transplantation.
|
| pubmed:grant | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/3-methylhistidine,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids, Branched-Chain,
http://linkedlifedata.com/resource/pubmed/chemical/Creatinine,
http://linkedlifedata.com/resource/pubmed/chemical/Methylhistidines,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrogen
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0148-6071
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
112-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:3295317-Adolescent,
pubmed-meshheading:3295317-Adult,
pubmed-meshheading:3295317-Amino Acids,
pubmed-meshheading:3295317-Amino Acids, Branched-Chain,
pubmed-meshheading:3295317-Bone Marrow Transplantation,
pubmed-meshheading:3295317-Clinical Trials as Topic,
pubmed-meshheading:3295317-Creatinine,
pubmed-meshheading:3295317-Double-Blind Method,
pubmed-meshheading:3295317-Female,
pubmed-meshheading:3295317-Humans,
pubmed-meshheading:3295317-Infusions, Intravenous,
pubmed-meshheading:3295317-Leukemia,
pubmed-meshheading:3295317-Male,
pubmed-meshheading:3295317-Methylhistidines,
pubmed-meshheading:3295317-Middle Aged,
pubmed-meshheading:3295317-Muscles,
pubmed-meshheading:3295317-Nitrogen,
pubmed-meshheading:3295317-Random Allocation,
pubmed-meshheading:3295317-Stress, Physiological
|
| pubmed:articleTitle |
Intravenous branched chain amino acid trial in marrow transplant recipients.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Research Support, U.S. Gov't, P.H.S.,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|