| pubmed-article:3273420 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3273420 | lifeskim:mentions | umls-concept:C0020205 | lld:lifeskim |
| pubmed-article:3273420 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
| pubmed-article:3273420 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:3273420 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:3273420 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:3273420 | lifeskim:mentions | umls-concept:C0036576 | lld:lifeskim |
| pubmed-article:3273420 | lifeskim:mentions | umls-concept:C1515895 | lld:lifeskim |
| pubmed-article:3273420 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:3273420 | pubmed:dateCreated | 1990-5-17 | lld:pubmed |
| pubmed-article:3273420 | pubmed:abstractText | In vitro cultured B16 melanoma cells, which were previously found to have an impaired expression of H-2Kb and Db (as evaluated by antisera absorption assay), were used to study growth and metastasis in allogeneic mice in relation to H-2 expression. The possible emergence of somatic hybrids with host cells was also examined. B16-A cells grown subcutaneously in allogeneic BALB/c mice (H-2d) did not show a lack of H-2b expression, nor the acquirement of H-2d antigens was found. Spontaneous lung metastases were found in about 30% of BALB/c mice with progressing B16 tumor. Single lung metastases showed higher H-2b levels than cells from the respective tumors, and did not express host H-2 antigens. Tumor take was concomitant to the rise of an anti-H-2b humoral response: disease outcome was independent from the serum titer. B16-A cells injected intravenously in BALB/c mice gave rise to lung colonies; different colonies showed a wide range of H-2b antigens levels and no H-2d expression. Lung colonization capacity in normal allogeneic BALB/c mice was significantly higher than in syngeneic C57BL/6 mice. Both syngeneic and allogeneic mice, when pretreated with cyclophosphamide (CY) to reduce natural killer cell activity, showed a significant increase in lung colonization by B16-A cells. CY-treated C57BL/6 mice showed significantly higher numbers of lung colonies than CY-treated BALB/c mice. In conclusion, B16 growth and metastasis in the allogeneic environment do not seem to be determined by a selection of H-2-negative variants or by the emergence of somatic hybrids with host cells. | lld:pubmed |
| pubmed-article:3273420 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3273420 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3273420 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3273420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3273420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3273420 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3273420 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3273420 | pubmed:issn | 0254-9670 | lld:pubmed |
| pubmed-article:3273420 | pubmed:author | pubmed-author:ProdiGG | lld:pubmed |
| pubmed-article:3273420 | pubmed:author | pubmed-author:NicolettiGG | lld:pubmed |
| pubmed-article:3273420 | pubmed:author | pubmed-author:NanniPP | lld:pubmed |
| pubmed-article:3273420 | pubmed:author | pubmed-author:De GiovanniCC | lld:pubmed |
| pubmed-article:3273420 | pubmed:author | pubmed-author:Del ReBB | lld:pubmed |
| pubmed-article:3273420 | pubmed:author | pubmed-author:LolliniP LPL | lld:pubmed |
| pubmed-article:3273420 | pubmed:author | pubmed-author:ScotlandiKK | lld:pubmed |
| pubmed-article:3273420 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3273420 | pubmed:volume | 4 | lld:pubmed |
| pubmed-article:3273420 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3273420 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3273420 | pubmed:pagination | 153-62 | lld:pubmed |
| pubmed-article:3273420 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3273420 | pubmed:meshHeading | pubmed-meshheading:3273420-... | lld:pubmed |
| pubmed-article:3273420 | pubmed:meshHeading | pubmed-meshheading:3273420-... | lld:pubmed |
| pubmed-article:3273420 | pubmed:meshHeading | pubmed-meshheading:3273420-... | lld:pubmed |
| pubmed-article:3273420 | pubmed:meshHeading | pubmed-meshheading:3273420-... | lld:pubmed |
| pubmed-article:3273420 | pubmed:meshHeading | pubmed-meshheading:3273420-... | lld:pubmed |
| pubmed-article:3273420 | pubmed:meshHeading | pubmed-meshheading:3273420-... | lld:pubmed |
| pubmed-article:3273420 | pubmed:meshHeading | pubmed-meshheading:3273420-... | lld:pubmed |
| pubmed-article:3273420 | pubmed:meshHeading | pubmed-meshheading:3273420-... | lld:pubmed |
| pubmed-article:3273420 | pubmed:meshHeading | pubmed-meshheading:3273420-... | lld:pubmed |
| pubmed-article:3273420 | pubmed:meshHeading | pubmed-meshheading:3273420-... | lld:pubmed |
| pubmed-article:3273420 | pubmed:year | 1987 | lld:pubmed |
| pubmed-article:3273420 | pubmed:articleTitle | Growth and metastasis in allogeneic hosts. Lack of H-2-negative or somatic hybrid variant selection. | lld:pubmed |
| pubmed-article:3273420 | pubmed:affiliation | Istituto di Cancerologia, Università di Bologna, Italia. | lld:pubmed |
| pubmed-article:3273420 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3273420 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
