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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1989-5-18
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pubmed:abstractText |
To understand the intrinsic mechanisms of vascular smooth muscle cell proliferation, we studied the growth of cultured rat aortic smooth muscle from spontaneously hypertensive rats (SHR) and their normotensive controls, Wistar-Kyoto rats (WKY), under basal conditions and after stimulation. Cell growth was assessed by the determination of cell number, and incorporation of 3H-thymidine into newly-synthesized DNA. We demonstrated that vascular smooth muscle cells from SHR proliferate faster and grow to a greater density, regardless of the initial plating number. The growth difference was not due to different plating efficiencies. Significantly higher 3H-thymidine incorporation was observed in vascular smooth muscle cells from SHR when the cells were stimulated by calf serum, platelet-derived growth factor or epidermal growth factor. Exposure to calf serum elicited an excessive expression of c-myc and c-fos in the first hour after stimulation. These results provide evidence of the hyper-responsiveness of vascular smooth muscle cells from SHR aortae to growth stimuli.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0952-1178
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
6
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
S36-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3266507-Animals,
pubmed-meshheading:3266507-Cell Division,
pubmed-meshheading:3266507-DNA,
pubmed-meshheading:3266507-Epidermal Growth Factor,
pubmed-meshheading:3266507-Hypertension,
pubmed-meshheading:3266507-Muscle, Smooth, Vascular,
pubmed-meshheading:3266507-Platelet-Derived Growth Factor,
pubmed-meshheading:3266507-Rats,
pubmed-meshheading:3266507-Rats, Inbred SHR
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pubmed:year |
1988
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pubmed:articleTitle |
Vascular smooth muscle cell hyper-responsiveness to growth factors in hypertension.
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pubmed:affiliation |
Clinical Research Institute of Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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