Linked Life Data

3264710

Source:http://linkedlifedata.com/resource/pubmed/id/3264710

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1989-2-23
pubmed:abstractText
1. We have compared acute gastric bleeding caused by a new slow release preparation of indomethacin (indomethacin Continus) with that caused by aspirin and other indomethacin preparations. 2. In a randomized crossover study, blood loss into timed gastric aspirates was determined in 20 healthy volunteers after receiving, over 96 h, either placebo, aspirin (600 mg four times daily; 17 doses) indomethacin BP (50 mg three times daily; 13 doses), Indocid-R (75 mg twice daily; 9 doses) or indomethacin Continus (75 mg twice daily; 9 doses). A venous blood sample was also taken during each treatment period for subsequent determination of alpha 1-glycoprotein, and for drug assay. 3. Gastric bleeding on placebo was 1.4 (0.7-2.8) microliters 10 min-1 (mean, 95% confidence interval). Both aspirin and the indomethacin preparations caused significantly more bleeding (P less than 0.05). Rates of bleeding after aspirin, indomethacin BP, Indocid-R, and indomethacin Continus were respectively 22.0 (10.7-47.2) microliters 10 min-1, 4.4 (2.2-9.1) microliters 10 min-1, 10.8 (5.3-22.3) microliters 10 min-1, and 5.1 (3.0-10.6) microliters 10 min-1. 4. Rates of bleeding after indomethacin BP and indomethacin Continus, but not Indocid-R, were significantly less than after aspirin (P less than 0.01). 5. Salicylate or indomethacin was detectable in the plasma of all subjects after the active treatment periods, except for one instance involving a subject allocated indomethacin BP. Indomethacin levels were significantly higher 2 h after Indocid-R than with indomethacin BP or indomethacin Continus. 6. alpha 1-acid glycoprotein levels were not significantly affected by prior treatment with aspirin or indomethacin.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-10217, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-2869207, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-3092655, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-3103204, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-313330, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-3466837, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-371938, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-3904441, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-3917814, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-3979908, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-4024217, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-409317, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-497567, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-5009716, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-520100, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-6416544, http://linkedlifedata.com/resource/pubmed/commentcorrection/3264710-6956930
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0306-5251
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
167-72
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Effect in man of aspirin, standard indomethacin, and sustained release indomethacin preparations on gastric bleeding.
pubmed:affiliation
Department of Therapeutics, University Hospital, Nottingham.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't