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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1989-1-19
|
| pubmed:abstractText |
Lethal effect of Listeria monocytogenes (L. monocytogenes) in mice was prevented by an intraperitoneal (ip) injection of a traditional Chinese herbal medicine, xiao-chai-hu-tang (Japanese name: shosaiko-to), 4 days before ip bacterial infection. The numbers of bacteria in the peritoneal cavity and liver were smaller in shosaiko-to-treated mice from one day after the infection. Macrophage accumulation in the peritoneal cavity after ip inoculation of L. monocytogenes was observed in both untreated and shosaiko-to-treated mice. Although rates of such increases were almost the same between both groups, the absolute number of macrophages was larger in shosaiko-to-treated than in untreated mice because of a higher level of the macrophage number at 4 days after ip injection of shosaiko-to. In untreated mice, bactericidal activity of peritoneal macrophages decreased from one day to 3 days after ip injection of killed L. monocytogenes. Such an activity was maintained at the same level from 1 to 3 days in shosaiko-to-treated mice. Augmented accumulation of macrophages and maintenance of their bactericidal activity may be main mechanisms of the augmented resistance in shosaiko-to-treated mice. Augmented resistance against bacterial growth in the thigh muscle in ip shosaiko-to-treated mice may be caused by such mechanisms. The effect of shosaiko-to observed at an early stage of infection may be T cell-independent, since such an effect was observed in athymic nude mice and delayed footpad reaction could not be detected at such a timing in euthymic normal mice.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0892-3973
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
10
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
345-64
|
| pubmed:dateRevised |
2010-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:3264299-Animals,
pubmed-meshheading:3264299-Anti-Bacterial Agents,
pubmed-meshheading:3264299-Drugs, Chinese Herbal,
pubmed-meshheading:3264299-Female,
pubmed-meshheading:3264299-Immunity, Cellular,
pubmed-meshheading:3264299-Listeriosis,
pubmed-meshheading:3264299-Macrophages,
pubmed-meshheading:3264299-Mice,
pubmed-meshheading:3264299-Mice, Inbred Strains,
pubmed-meshheading:3264299-Mice, Nude,
pubmed-meshheading:3264299-Peritoneal Cavity,
pubmed-meshheading:3264299-T-Lymphocytes
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
Protective effect of a traditional Chinese medicine, xiao-chai-hu-tang (Japanese name: shosaiko-to), on Listeria monocytogenes infection in mice.
|
| pubmed:affiliation |
Kampo (Traditional Chinese Medicine) Research Laboratories, Kanebo Co. Ltd., Osaka, Japan.
|
| pubmed:publicationType |
Journal Article
|