Linked Life Data

3261574

Source:http://linkedlifedata.com/resource/pubmed/id/3261574

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1988-9-16
pubmed:abstractText
The response to the T-cell growth factor interleukin-2 (IL-2) and to phytohemagglutinin (PHA) and concanavalin A (Con-A) were investigated in 63 patients with alopecia areata (AA) and in control subjects. The proliferative response to mitogens and to IL-2 determined by measuring [3H]-thymidine incorporation 72 h after stimulation is generally decreased in AA patients. The response to mitogens and to IL-2 was related to the response to the topical sensitizer SADBE (squaric acid dibutylester) and patients with no allergic reaction to this substance showed a marked reduction in lymphocyte stimulation, especially with IL-2. HLA typing of 34 of the 63 AA patients was performed in order to investigate the immunogenetic basis of hyporesponsiveness to topical sensitization. The relationship between reduced in vitro response to mitogens and particularly to IL-2, and in vivo response to sensitization to SADBE and the presence of HLA-DR5 are discussed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0340-3696
pubmed:author
pubmed:issnType
Print
pubmed:volume
280 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S47-50
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Decreased in vitro lymphocyte stimulation and reduced sensitivity to IL-2 in patients with alopecia areata.
pubmed:affiliation
Clinica Dermatologica, Università di Pavia, Italy.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't