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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1989-6-19
|
| pubmed:abstractText |
Mexiprostil is a new gastroprotective 16-methoxy-16-methyl-PGE1 methyl ester. To assign the absolute configuration at C-15, a crystalline high-melting C-1 ester analog 5 11,15-dihydroxy-16-methoxy-16-methyl-9-oxoprost-13-en-1-oic acid 4-(4-bromobenzamide)phenyl ester (15R, 16R) was prepared and submitted to single crystal X-ray analysis. Since C-8, C-11, C-12 and C-16 are shown to have R configurations, the X-ray diffraction results established that the configuration at C-15 is also R.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0090-6980
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
639-49
|
| pubmed:dateRevised |
2000-12-18
|
| pubmed:meshHeading |
pubmed-meshheading:3247474-Alprostadil,
pubmed-meshheading:3247474-Anti-Ulcer Agents,
pubmed-meshheading:3247474-Magnetic Resonance Spectroscopy,
pubmed-meshheading:3247474-Models, Molecular,
pubmed-meshheading:3247474-Molecular Conformation,
pubmed-meshheading:3247474-Molecular Structure,
pubmed-meshheading:3247474-X-Ray Diffraction
|
| pubmed:year |
1988
|
| pubmed:articleTitle |
X-ray structure determination of mexiprostil, a new gastroprotective 16-methoxy-16-methyl-PGE1 analogue.
|
| pubmed:affiliation |
Department of Diffractometry, CNR, University of Parma, Italy.
|
| pubmed:publicationType |
Journal Article
|