Linked Life Data

3243201

Source:http://linkedlifedata.com/resource/pubmed/id/3243201

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-5-26
pubmed:abstractText
The erythrocytes were used as a model system to study insulin receptors in diabetic patients with highly increased insulin resistance. The specific binding of 125I-insulin to erythrocytes of these patients was markedly reduced. When erythrocytes prepared from non-diabetic subjects were exposed to serum of these patients, the decrease of insulin binding was reproduced. The binding of insulin showed a displacement curve that is parallel to the control values over the same range of hormone concentration, even in the case when control erythrocytes were preincubated with serum of diabetics with increased insulin resistance. These results indicate the presence of certain component in blood plasma of examined patients which alters insulin binding to receptors. The developed assay provides an efficient method for detection and identification of substances presented in the serum which can influence the binding of insulin to the specific sites as well as its biological effects.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0013-7200
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Detection of compounds in serum inhibiting insulin binding to erythrocyte receptors.
pubmed:affiliation
Institute for Nuclear Sciences Boris Kidric, Faculty of Medicine, Belgrade, Yugoslavia.
pubmed:publicationType
Journal Article