Linked Life Data

3241220

Source:http://linkedlifedata.com/resource/pubmed/id/3241220

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-5-18
pubmed:abstractText
Phospholipase C activity, which influences the control of platelet physiological responses, was investigated in platelets of human essential hypertensives and of spontaneously hypertensive rats (SHR) compared with appropriate normotensive controls, in order to determine whether this enzyme activity could account for the enhanced platelet responses exhibited by hypertensive subjects. After 32P-labelling of cells, the enzyme activity was estimated by measuring the variations in 32P-phosphatidic acid. In resting platelets no difference was observed between hypertensives and normotensives. In contrast, the thrombin-induced increase in 32P-phosphatidic acid in platelets of human hypertensives and of SHR was 30% higher than in controls, suggesting hypersensitivity to phospholipase C in hypertensives. Since, as revealed by phorbol-stimulated phosphorylation of 47-kilodalton protein, intrinsic protein kinase C activity is similar in SHR and controls, our data strengthen the hypothesis than hypersensitivity to phospholipase C influences the hyperreactivity of platelets in primary hypertension.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0952-1178
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S372-4
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Impaired phospholipase C activity is involved in the hyperreactivity of platelets in primary hypertension.
pubmed:affiliation
Départment de Pharmacologie, Hôpital Necker, Paris, France.
pubmed:publicationType
Journal Article