Linked Life Data

3233880

Source:http://linkedlifedata.com/resource/pubmed/id/3233880

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1989-4-27
pubmed:abstractText
A study of MHC class I, II, and III markers in a group of southern Chinese in Hong Kong is reported. HLA antigen frequencies and complement allele frequencies are given, together with statistically significant pair-wise co-occurrences. Over half of the statistically significant positive and negative linkage disequilibria relate to two extended haplotypes. These haplotypes, or components of them, are associated with a number of diseases in Chinese, particularly diseases of autoimmune origin. One haplotype, A2, Bw46, DRw9, appears to be an analogue of the haplotype A1, B8, DR3 which predisposes to similar diseases in Caucasians. The question is raised of why susceptibility to the same group of diseases in two different racial groups should be related to the haplotypes having the strongest linkage disequilibria within those racial groups.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0278-0240
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
237-45
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:articleTitle
Distribution and co-occurrence of MHC class I, II, and III markers in southern Chinese: implications for autoimmune disease.
pubmed:affiliation
Department of Pathology, University of Hong Kong.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't