Linked Life Data

3229625

Source:http://linkedlifedata.com/resource/pubmed/id/3229625

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1989-4-20
pubmed:abstractText
1. Chronic morphine administration to rats produced diverse ultrastructural alterations in nerve cells and neuropile of caudate nucleus, cerebral cortex and hippocampus through a short term abstinence period. 2. All areas studied showed increasing damage related to time elapsed between the last morphine injection and animal sacrifice. 3. Intracytoplasmic neuronal membranous organelles mainly suffered severe swelling, membrane disarrangement and eventually cell disruption in all areas studied. 4. Hippocampus was the most affected area throughout the study, followed by caudate nucleus and cerebral cortex, where focal damage was seen. 5. Susceptibility to morphine cytotoxic effect in the three areas studied appears to be unrelated to their opiate receptor density. 6. Mitochondrial alterations produced by morphine could be related to interference of the intracellular energy production system and consequent unrestricted cell membrane permeability to water and solutes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0306-3623
pubmed:author
pubmed:issnType
Print
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
841-8
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1988
pubmed:articleTitle
Ultrastructural alterations in caudate nucleus, cerebral cortex and hippocampus produced by morphine.
pubmed:affiliation
Laboratory of Experimental Neuropathology, Unidad de Investigación Biomédica de Occidente, I.M.S.S., México City, Mexico.
pubmed:publicationType
Journal Article