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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1989-3-27
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pubmed:abstractText |
The plasma protein distribution of oestradiol (E2) and oestrone (E1) during transdermal E2 administration (100 micrograms/24 hr) was studied in 12 post-menopausal women. The E2 and E1 levels observed were 43-83 pg/ml and 37-73 pg/ml, respectively. The levels of the free, albumin-bound and sex-hormone-binding globulin (SHBG) bound fractions were in the ranges 1.4-1.9%, 60-65% and 35-45%, respectively, in the case of E2, and 2.8-3.0%, 80-89% and 15-20%, respectively, in that of E1. The SHBG levels also remained unaltered. It was concluded that transdermal administration of E2 at the dosage employed produces a physiological plasma protein distribution of E2 and E1 and does not affect liver protein production.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0378-5122
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
263-70
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:3226336-Administration, Cutaneous,
pubmed-meshheading:3226336-Blood Proteins,
pubmed-meshheading:3226336-Estradiol,
pubmed-meshheading:3226336-Estrone,
pubmed-meshheading:3226336-Female,
pubmed-meshheading:3226336-Humans,
pubmed-meshheading:3226336-Menopause,
pubmed-meshheading:3226336-Middle Aged,
pubmed-meshheading:3226336-Protein Binding,
pubmed-meshheading:3226336-Sex Hormone-Binding Globulin
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pubmed:year |
1988
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pubmed:articleTitle |
Biological and endocrine aspects of transdermal 17 beta-oestradiol administration in post-menopausal women.
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pubmed:affiliation |
Reproductive Medicine Unit, University of Bologna, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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