| pubmed-article:3223900 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C0227525 | lld:lifeskim |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C0019932 | lld:lifeskim |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C0017687 | lld:lifeskim |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C0521451 | lld:lifeskim |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C0441472 | lld:lifeskim |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C0030012 | lld:lifeskim |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C0019409 | lld:lifeskim |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C1749497 | lld:lifeskim |
| pubmed-article:3223900 | lifeskim:mentions | umls-concept:C0599816 | lld:lifeskim |
| pubmed-article:3223900 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:3223900 | pubmed:dateCreated | 1989-3-17 | lld:pubmed |
| pubmed-article:3223900 | pubmed:abstractText | Hepatocytes isolated from the periportal or perivenous zones of livers of fed rats were used to study the long-term (14 h) and short-term (2 h) effects of glucagon on gluconeogenesis and ketogenesis. Long-term culture with glucagon (100 nM) resulted in a greater increase (P less than 0.01) in gluconeogenesis in periportal than in perivenous cells (93 +/- 16 versus 30 +/- 14 nmol/h per mg of protein; 72% versus 30% increase), but short-term incubation (2 h) with glucagon resulted in similar stimulation in the two cell populations. Rates of ketogenesis (acetoacetate and D-3-hydroxybutyrate production) were not significantly higher in periportal cells cultured without glucagon, compared with perivenous cells. However, after long-term culture with glucagon, the periportal cells had a significantly higher rate of ketogenesis (from either palmitate or octanoate as substrate), but a lower 3-hydroxybutyrate/acetoacetate production ratio, suggesting a more oxidized mitochondrial NADH/NAD+ redox state despite the higher rate of beta-oxidation. Periportal hepatocytes had a higher activity of carnitine palmitoyltransferase but a lower activity of citrate synthase than did perivenous cells. These findings suggest that: (i) glucagon elicits greater long-term stimulation of gluconeogenesis in periportal than in perivenous hepatocytes maintained in culture; (ii) after culture with glucagon, the rates of ketogenesis and the mitochondrial redox state differ in periportal and perivenous hepatocytes. | lld:pubmed |
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| pubmed-article:3223900 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3223900 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3223900 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:3223900 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3223900 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:3223900 | pubmed:issn | 0264-6021 | lld:pubmed |
| pubmed-article:3223900 | pubmed:author | pubmed-author:AlbertiG MGM | lld:pubmed |
| pubmed-article:3223900 | pubmed:author | pubmed-author:SNOWR ERE | lld:pubmed |
| pubmed-article:3223900 | pubmed:author | pubmed-author:AgiusLL | lld:pubmed |
| pubmed-article:3223900 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3223900 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:3223900 | pubmed:volume | 256 | lld:pubmed |
| pubmed-article:3223900 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3223900 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3223900 | pubmed:pagination | 197-204 | lld:pubmed |
| pubmed-article:3223900 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:3223900 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3223900 | pubmed:articleTitle | Glucagon regulation of gluconeogenesis and ketogenesis in periportal and perivenous rat hepatocytes. Heterogeneity of hormone action and of the mitochondrial redox state. | lld:pubmed |
| pubmed-article:3223900 | pubmed:affiliation | Department of Medicine, University of Newcastle upon Tyne, U.K. | lld:pubmed |
| pubmed-article:3223900 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3223900 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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