| pubmed-article:3220425 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:3220425 | lifeskim:mentions | umls-concept:C0018787 | lld:lifeskim |
| pubmed-article:3220425 | lifeskim:mentions | umls-concept:C0027747 | lld:lifeskim |
| pubmed-article:3220425 | lifeskim:mentions | umls-concept:C0022616 | lld:lifeskim |
| pubmed-article:3220425 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:3220425 | lifeskim:mentions | umls-concept:C0599861 | lld:lifeskim |
| pubmed-article:3220425 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:3220425 | pubmed:dateCreated | 1989-3-23 | lld:pubmed |
| pubmed-article:3220425 | pubmed:abstractText | The potential cardiac presynaptic effects of ketanserin (K) (0.01-3.00 mg/kg IV) were investigated in pithed SHR in 4 experimental conditions: (a) basal heart rate (HR); (b) HR increased by selective cardiac sympathetic stimulation (SS); (c) HR increased by aminophylline infusion; and (d) HR increased by SS and brought back to basal value by clonidine. Control groups were treated with saline. In the 4 types of experiments, K, starting from 0.3 mg/kg, induced almost identical and dose-dependent decreases in HR (maximal reduction: 45 beats/(min at 3 mg/kg). Thus we conclude: (1) that K is devoid of any presynaptic facilitatory effect on norepinephrine release since it was unable to raise HR in experiment D; (2) that K is devoid of any presynaptic inhibitory effect on norepinephrine release since it lowered HR to the same extent in both experiments B (noradrenergic tachycardia) and (non-noradrenergic tachycardia); and C (3) that the bradycardia which was induced by high doses of K (much above those required to block 5-HT2 and alpha 1-adrenergic receptors) and which was of similar magnitude in the 4 experimental conditions is probably due to a direct, nonspecific depressant effect of K on the sinus node. | lld:pubmed |
| pubmed-article:3220425 | pubmed:language | eng | lld:pubmed |
| pubmed-article:3220425 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3220425 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:3220425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3220425 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:3220425 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:3220425 | pubmed:issn | 0767-3981 | lld:pubmed |
| pubmed-article:3220425 | pubmed:author | pubmed-author:GiudicelliJ... | lld:pubmed |
| pubmed-article:3220425 | pubmed:author | pubmed-author:RicherCC | lld:pubmed |
| pubmed-article:3220425 | pubmed:author | pubmed-author:ScalbertEE | lld:pubmed |
| pubmed-article:3220425 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:3220425 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:3220425 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:3220425 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:3220425 | pubmed:pagination | 295-9 | lld:pubmed |
| pubmed-article:3220425 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:meshHeading | pubmed-meshheading:3220425-... | lld:pubmed |
| pubmed-article:3220425 | pubmed:year | 1988 | lld:pubmed |
| pubmed-article:3220425 | pubmed:articleTitle | Lack of presynaptic effects of ketanserin on cardiac noradrenergic nerve terminals in the SHR. | lld:pubmed |
| pubmed-article:3220425 | pubmed:affiliation | Département de Pharmacologie, Faculté de Médecine, Le Kremlin-Bicêtre, France. | lld:pubmed |
| pubmed-article:3220425 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:3220425 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
