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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1977-5-27
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pubmed:abstractText |
Studies involving the combined use of phytohaemagglutinin (PHA) and cyclophosphamide (CY) indicate that both agents can act together to produce immunological unresponsiveness: following injection of PHA into mice, splenic DNA synthetic responses [14C]thymidine incorporation) and haemolysin plaque formation against sheep red blood cells were determined in daily intervals. Both immunosuppression and DNA synthetic activity were maximally developed 5 days after treatment with PHA. Administration of CY at this time resulted in immunological unresponsiveness lasting for about 18 days. Antibody production could be completely restored with antigen-activated T cells (but not with B cells), thus indicating a selective inhibition of T-cell 'helper function' in mice treated with PHA and CY. This observation is consistent with the general assumption that cells involved in the response to PHA are predominantly T cells. Apparently, these cells are highly sensitive to an inactivation by CY after stimulation with PHA.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-12635259,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-17815805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-4111088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-4132062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-4538884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-4544177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-4551583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-4588912,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-4598017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-4606666,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-4945477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5001843,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5010393,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5046868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5065602,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5274344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5337282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5413326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5455142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5534450,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5684863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5691985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5793185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5912615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-5965513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/321157-6034749
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
178-82
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pubmed:dateRevised |
2010-9-2
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pubmed:meshHeading |
pubmed-meshheading:321157-Adult,
pubmed-meshheading:321157-Animals,
pubmed-meshheading:321157-Antibody Formation,
pubmed-meshheading:321157-Cyclophosphamide,
pubmed-meshheading:321157-DNA,
pubmed-meshheading:321157-Female,
pubmed-meshheading:321157-Hemolytic Plaque Technique,
pubmed-meshheading:321157-Humans,
pubmed-meshheading:321157-Lectins,
pubmed-meshheading:321157-Lymphocyte Activation,
pubmed-meshheading:321157-Male,
pubmed-meshheading:321157-Mice,
pubmed-meshheading:321157-Mice, Inbred Strains,
pubmed-meshheading:321157-Spleen,
pubmed-meshheading:321157-T-Lymphocytes,
pubmed-meshheading:321157-Time Factors
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pubmed:year |
1977
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pubmed:articleTitle |
Drug-induced immunological unresponsiveness: selective inhibition of T-cell 'helper function' by cyclophosphamide in mice pretreated with phytohaemagglutinin.
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pubmed:publicationType |
Journal Article
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